Host cell macromolecular synthesis was studied in EBV-infected Raji cells, containing the intranuclear early antigens (EA), by combined immunofluorescence and autoradiography. DNA, RNA, and protein synthesis was inhibited in EA+ cells. Membrane antigen (MA) positive, EA negative cells continued an apparently uninfluenced RNA and protein synthesis. The proportion of DNA synthesizing MA+EA- cells was lower than among antigen negative (MA-EA-) cells, but this may be related to the reduced expression of membrane antigens during and after the S phase.
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