Hormonal regulation of phosphorylase phosphatase activity in rat liver

Ilona Farkas, Béla Tóth, György Bot, Pál Gergely

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Abstract

The effect of glucagon and insulin on rat liver phosphorylase phosphatase activity in vivo was investigated. The activity of phosphatase was found to decrease following the administration of glucagon and increase with insulin in a reversible manner. No change was detected in the activity of heat-stable phosphatase inhibitors in the hormone-treated samples. Liver protein kinases (regulatory subunit of cAMP-dependent protein kinase and/or Ca2+ -dependent phosphorylase kinase) are suggested to regulate the activity of hepatic phosphorylase phosphatase (type 1 and 2A).

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalFEBS letters
Volume203
Issue number2
DOIs
Publication statusPublished - Jul 28 1986

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Keywords

  • Glycogen metabolism
  • Hormonal regulation
  • Protein phosphatase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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