Hormonal regulation of CYP1A expression Hormonal regulation of CYP1A expression Monostory et al.

Katalin Monostory, Jean Marc Pascussi, László Kóbori, Zdenek Dvorak

Research output: Contribution to journalReview article

69 Citations (Scopus)

Abstract

Aryl hydrocarbon receptor (AhR) is primarily involved in the transcriptional regulation of CYP1A enzymes, which are the main catalysts of the metabolic activation or inactivation of numerous procarcinogens, carcinogens, environmental toxicants, or therapeutic agents. Several endogenous factors, including hormones, can modify CYP1A induction, directly influencing CYP1A gene expression or AhR function or indirectly via crosstalks with other transcription factors. In this article, we summarize the current knowledge about the role of hormones (i.e., glucocorticoids, estrogens, progesterone, androgens, insulin, and glucagon) and hormone receptors as well as other essential factors (e.g., vitamin D, retinoids) in the modulation of CYP1A expression.

Original languageEnglish
Pages (from-to)547-572
Number of pages26
JournalDrug Metabolism Reviews
Volume41
Issue number4
DOIs
Publication statusPublished - Nov 1 2009

Keywords

  • Aryl hydrocarbon receptor
  • CYP1A enzymes
  • Drug metabolism
  • Glucocorticoids
  • Insulin
  • Nuclear receptors
  • Retinoids
  • Sexual steroids
  • Thyroid hormones
  • Vitamin D

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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