Hormonal characterization and classification of breast cyst fluid in gross cystic mastopathy

I. Számel, B. Budai, K. Daubner, J. Kralovánszky, Sz Ottó, J. Tóth, I. Besznyák

Research output: Contribution to journalArticle

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Abstract

Gross cystic disease (GCD) of the breast may be associated with a higher risk for the development of breast cancer. High levels of sex steroids, steroid hormone precursors, prolactin and cations have been found in breast cyst fluid (BCF) by several investigators. Accordingly, endocrine parameters and the cationic composition of BCF may be considered as useful characteristics to follow patients bearing macrocysts. In this study we have investigated the concentrations of estradiol (E2), progesterone, testosterone, dehydroepiandrosterone (DHA) and DHA-3-sulfate (DHA-S), prolactin, potassium (K+) and sodium (Na+) in BCF aspirated from 99 women. The mean age of the patients was 49.8 years (range 32-58). The hormone levels were measured by RIA methods; K+ and Na+ were determined by flame photometry. Estradiol, progesterone, testosterone, DHA, DHA-S, prolactin and K+ showed significant accumulation in the BCF compared with their respective serum values. The K+/Na+ ratio proved to be useful in dividing cysts into type I (≥1), type II (2 and DHA-S (r = 0.686), and also between testosterone and DHA-S (r = 0.711). These findings indicate that type I BCF might be a marker for 'active' GCD of the breast, and suggest that it may be associated with an increased breast cancer risk, since this group of patients is supposed to have cysts with apocrine metaplasia. It is suggested therefore that when BCF is aspirated, sex steroids, steroid precursors and cations should be routinely measured, and women with type I cysts should be regularly examined.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalEndocrine-Related Cancer
Volume1
Issue number2
Publication statusPublished - 1994

Fingerprint

Breast Cyst
Cyst Fluid
Dehydroepiandrosterone
Steroids
Fibrocystic Breast Disease
Prolactin
Testosterone
Cysts
Progesterone
Cations
Estradiol
Hormones
Breast Neoplasms
Photometry
Dehydroepiandrosterone Sulfate
Metaplasia
Potassium
Sodium
Research Personnel
Serum

ASJC Scopus subject areas

  • Cancer Research
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Oncology

Cite this

Számel, I., Budai, B., Daubner, K., Kralovánszky, J., Ottó, S., Tóth, J., & Besznyák, I. (1994). Hormonal characterization and classification of breast cyst fluid in gross cystic mastopathy. Endocrine-Related Cancer, 1(2), 49-55.

Hormonal characterization and classification of breast cyst fluid in gross cystic mastopathy. / Számel, I.; Budai, B.; Daubner, K.; Kralovánszky, J.; Ottó, Sz; Tóth, J.; Besznyák, I.

In: Endocrine-Related Cancer, Vol. 1, No. 2, 1994, p. 49-55.

Research output: Contribution to journalArticle

Számel, I, Budai, B, Daubner, K, Kralovánszky, J, Ottó, S, Tóth, J & Besznyák, I 1994, 'Hormonal characterization and classification of breast cyst fluid in gross cystic mastopathy', Endocrine-Related Cancer, vol. 1, no. 2, pp. 49-55.
Számel, I. ; Budai, B. ; Daubner, K. ; Kralovánszky, J. ; Ottó, Sz ; Tóth, J. ; Besznyák, I. / Hormonal characterization and classification of breast cyst fluid in gross cystic mastopathy. In: Endocrine-Related Cancer. 1994 ; Vol. 1, No. 2. pp. 49-55.
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