Hormonal changes during a prolonged tamoxifen treatment in patients with advanced breast cancer

Irene Számel, B. Vincze, Ivan Hindy, Ilona Hermann, János Borvendég, Sándar Eckhardt

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The effect of tamoxifen (ΤΑΜ) on the serum levels of sexual hormones and on the sex hormone-binding globulin (SHBG) was investigated in 30 postmenopausal patients with advanced breast cancer. To study the ‘prolactin reserve capacity’ of the pituitary gland, thyrotrophin-releasing hormone (TRH) and sulpiride-induced prolactin release were measured prior to ΤΑΜ treatment, then in the 2nd and 8th week of the therapy. The TRH (400 µg i.v.)-induced prolactin secretion was significantly suppressed by ΤΑΜ after an 8-week treatment, but only in responding cases. Maximal prolactin stimulation occurred at the 15th min after TRH injection, being equal to 5,600 ± 800 mlU/l in cancer patients, and decreasing to 2,400± 150 mlU/l after 8 weeks. ΤΑΜ did not suppress the sulpiride-inducable prolactin release either in responders or in nonresponders.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalOncology
Volume43
Issue number1
DOIs
Publication statusPublished - 1986

Fingerprint

Tamoxifen
Prolactin
Breast Neoplasms
Thyrotropin
Hormones
Sulpiride
Therapeutics
Sex Hormone-Binding Globulin
Pituitary Gland
Injections
Serum
Neoplasms

Keywords

  • Breast cancer
  • Prolactin
  • Sexual hormones
  • Tamoxifen treatment
  • TRH and sulpiride-induced prolactin release

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hormonal changes during a prolonged tamoxifen treatment in patients with advanced breast cancer. / Számel, Irene; Vincze, B.; Hindy, Ivan; Hermann, Ilona; Borvendég, János; Eckhardt, Sándar.

In: Oncology, Vol. 43, No. 1, 1986, p. 7-11.

Research output: Contribution to journalArticle

Számel, I, Vincze, B, Hindy, I, Hermann, I, Borvendég, J & Eckhardt, S 1986, 'Hormonal changes during a prolonged tamoxifen treatment in patients with advanced breast cancer', Oncology, vol. 43, no. 1, pp. 7-11. https://doi.org/10.1159/000226095
Számel, Irene ; Vincze, B. ; Hindy, Ivan ; Hermann, Ilona ; Borvendég, János ; Eckhardt, Sándar. / Hormonal changes during a prolonged tamoxifen treatment in patients with advanced breast cancer. In: Oncology. 1986 ; Vol. 43, No. 1. pp. 7-11.
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