Horka, a dominant mutation of Drosophila, induces nondisjunction and, through paternal effect, chromosome loss and genetic mosaics

J. Szabad, E. Mathe, J. Puro

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Fs(3)Horka (Horka) was described as a dominant female-sterile mutation of Drosophila melanogaster. Genetic and cytological data show that Horka induces mostly equational nondisjunction during spermatogenesis but not chromosome loss and possesses a dominant paternal effect: the X, second, third and the fourth chromosomes, but not the Y, are rendered unstable while undergoing spermatogenesis and may be lost in the descending zygotes. The frequency of Horka-induced chromosome loss is usually 2-4% but varies with the genetic background and can be over 20%. The X chromosome loss occurs during the gonomeric and the initial cleavage divisions. Loss of the X and fourth chromosomes shows no correlation. We propose, based on similarities in the mutant phenotypes with the chromosome destabilizing mutations nonclaret disjunctional and paternal loss, that the normal Horka+ product is required for function of the centromeres and/or nearby regions. Horka is a convenient tool for the generation of gynandromorphs, autosome mosaics and for the study of gene expression in mosaics.

Original languageEnglish
Pages (from-to)1585-1599
Number of pages15
JournalGenetics
Volume139
Issue number4
Publication statusPublished - 1995

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Drosophila
Chromosomes
X Chromosome
Spermatogenesis
Mutation
Centromere
Zygote
Y Chromosome
Drosophila melanogaster
Phenotype
Gene Expression
Paternal Inheritance
Genetic Background

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Horka, a dominant mutation of Drosophila, induces nondisjunction and, through paternal effect, chromosome loss and genetic mosaics. / Szabad, J.; Mathe, E.; Puro, J.

In: Genetics, Vol. 139, No. 4, 1995, p. 1585-1599.

Research output: Contribution to journalArticle

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