Horizontal gene transfer depends on gene content of the host

C. Pál, B. Papp, Martin J. Lercher

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Horizontal gene transfer is a major contributor to the evolution of bacterial genomes. We examine this process through a combination of comparative genomics and in silico analysis of the Escherichia coli metabolic network. We validate our horizontal transfer estimates by confirming the predicted gradual amelioration of GC content over time. We find that the chance of acquiring a gene by horizontal transfer is up to six times higher if an enzyme that catalyses a coupled metabolite flux is already encoded in the host genome.

Original languageEnglish
JournalBioinformatics
Volume21
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Sep 2005

Fingerprint

Gene transfer
Horizontal Gene Transfer
Horizontal
Genes
Gene
Bacterial Genomes
Base Composition
Genome
Genomics
Metabolic Networks and Pathways
Computer Simulation
Comparative Genomics
Metabolic Network
Escherichia coli
Metabolites
Escherichia Coli
Enzymes
Fluxes
Estimate

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Biochemistry
  • Molecular Biology
  • Computational Mathematics
  • Statistics and Probability

Cite this

Horizontal gene transfer depends on gene content of the host. / Pál, C.; Papp, B.; Lercher, Martin J.

In: Bioinformatics, Vol. 21, No. SUPPL. 2, 09.2005.

Research output: Contribution to journalArticle

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