Homologies between small nuclear RNAs and LAV HTLV-III sequences and their possible role in the cytopathic effect of the virus

J. Minárovits, J. Segesdi, Z. Kovács, I. Földes

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The mechanism of action of LAV HTLV-III resulting in a pronounced cytopathic effect is still unknown. We demonstrate that the long terminal repeat (LTR) sequence and env gene of LAV HTLV-III contain regions of 70-80% homology and/or complementarity with regions of small nuclear (sn) RNAs U1 and U2. On this basis, we hypothesize that the cytotoxic effect of LAV HTLV-III is due - at least partly - to the inhibition of processing of cellular hnRNAs by competing for splice junction sites and/or by complexing with U1 and especially U2 RNAs.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalMedical hypotheses
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1987

ASJC Scopus subject areas

  • Medicine(all)

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