Homologies between a brain-specific identifier (ID) sequence and regions of Harvey murine sarcoma virus and Rous sarcoma virus genomes. Putative role of identifier sequences in the tissue specificity of malignant transformation by RNA tumor viruses

J. Mináróvits, Zoltán Kovács, István Földes

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

As a step toward understanding of the tissue specificity of cellular transformation by RNA tumor viruses we looked for the presence of a putative brain specific regulatory (identifier) sequence (C82B) in the genome of various oncornaviruses. The genomes of Harvey murine sarcoma virus and Rous sarcoma virus contain sequences flanking the viral oncogenes with > 80% and > 60% homology to C82B, respectively. We suggest that identifier sequences acquired by oncoviruses may determine the potential target cells of malignant transformation after virus penetration. Nucleic acid homology RNA tumor virus Identifier sequence Cell transformation Tissue specificity.

Original languageEnglish
Pages (from-to)208-210
Number of pages3
JournalFEBS Letters
Volume174
Issue number2
DOIs
Publication statusPublished - Sep 3 1984

Fingerprint

Harvey murine sarcoma virus
Rous sarcoma virus
Organ Specificity
Retroviridae
Viruses
Tumors
Brain
Genes
Genome
RNA
Tissue
Oncogenes
Nucleic Acids

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

@article{b7762cbdb8b64e9abc8a4df77979506a,
title = "Homologies between a brain-specific identifier (ID) sequence and regions of Harvey murine sarcoma virus and Rous sarcoma virus genomes. Putative role of identifier sequences in the tissue specificity of malignant transformation by RNA tumor viruses",
abstract = "As a step toward understanding of the tissue specificity of cellular transformation by RNA tumor viruses we looked for the presence of a putative brain specific regulatory (identifier) sequence (C82B) in the genome of various oncornaviruses. The genomes of Harvey murine sarcoma virus and Rous sarcoma virus contain sequences flanking the viral oncogenes with > 80{\%} and > 60{\%} homology to C82B, respectively. We suggest that identifier sequences acquired by oncoviruses may determine the potential target cells of malignant transformation after virus penetration. Nucleic acid homology RNA tumor virus Identifier sequence Cell transformation Tissue specificity.",
author = "J. Min{\'a}r{\'o}vits and Zolt{\'a}n Kov{\'a}cs and Istv{\'a}n F{\"o}ldes",
year = "1984",
month = "9",
day = "3",
doi = "10.1016/0014-5793(84)81158-8",
language = "English",
volume = "174",
pages = "208--210",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Homologies between a brain-specific identifier (ID) sequence and regions of Harvey murine sarcoma virus and Rous sarcoma virus genomes. Putative role of identifier sequences in the tissue specificity of malignant transformation by RNA tumor viruses

AU - Mináróvits, J.

AU - Kovács, Zoltán

AU - Földes, István

PY - 1984/9/3

Y1 - 1984/9/3

N2 - As a step toward understanding of the tissue specificity of cellular transformation by RNA tumor viruses we looked for the presence of a putative brain specific regulatory (identifier) sequence (C82B) in the genome of various oncornaviruses. The genomes of Harvey murine sarcoma virus and Rous sarcoma virus contain sequences flanking the viral oncogenes with > 80% and > 60% homology to C82B, respectively. We suggest that identifier sequences acquired by oncoviruses may determine the potential target cells of malignant transformation after virus penetration. Nucleic acid homology RNA tumor virus Identifier sequence Cell transformation Tissue specificity.

AB - As a step toward understanding of the tissue specificity of cellular transformation by RNA tumor viruses we looked for the presence of a putative brain specific regulatory (identifier) sequence (C82B) in the genome of various oncornaviruses. The genomes of Harvey murine sarcoma virus and Rous sarcoma virus contain sequences flanking the viral oncogenes with > 80% and > 60% homology to C82B, respectively. We suggest that identifier sequences acquired by oncoviruses may determine the potential target cells of malignant transformation after virus penetration. Nucleic acid homology RNA tumor virus Identifier sequence Cell transformation Tissue specificity.

UR - http://www.scopus.com/inward/record.url?scp=0021160069&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021160069&partnerID=8YFLogxK

U2 - 10.1016/0014-5793(84)81158-8

DO - 10.1016/0014-5793(84)81158-8

M3 - Article

C2 - 6088289

AN - SCOPUS:0021160069

VL - 174

SP - 208

EP - 210

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 2

ER -