Homogeneous immunoglobulins following allogeneic bone marrow transplantation

Melinda Hajdu, Éva Puskás, Andrea Sipos, Anikó Barta, K. Pálóczi, F. Uher

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Homogeneous immunoglobulins are frequently detected in the serum of patients undergoing allogeneic bone marrow transplantation (BMT). The aim of the present study was to further characterize the incidence of this phenomenon and its correlations with laboratory and clinical data. Serum samples were gathered from 29 patients undergoing allogeneic or syngeneic BMT for chronic myeloid leukemia (CML), and serial protein (IgG, IgA and IgM) quantification, electrophoresis and immunofixation were performed. Transient mono- or oligoclonal gammopathies were observed in 23 out of 29 patients between days 20 and 1,750 following transplantation. The presence of homogeneous immunoglobulins was not correlated with the following clinical parameters: graft-versus-host disease, bacterial sepsis, Epstein-Barr virus or cytomegalovirus infection or invasive fungal infection. Therefore, the development of mono- or oligoclonal immunoglobulins may represent a complex disorder of B cell regeneration which may be caused by an intrinsic B cell defect, or a failure in the regenerating T cell system, or both, manifesting itself in a restricted antibody diversity after allogeneic BMT.

Original languageEnglish
Pages (from-to)124-128
Number of pages5
JournalActa Haematologica
Volume109
Issue number3
DOIs
Publication statusPublished - 2003

Fingerprint

Homologous Transplantation
Bone Marrow Transplantation
Immunoglobulins
B-Lymphocytes
Antibody Diversity
Isogeneic Transplantation
Oligoclonal Bands
Epstein-Barr Virus Infections
Cytomegalovirus Infections
Graft vs Host Disease
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Serum
Immunoglobulin A
Immunoglobulin M
Electrophoresis
Regeneration
Sepsis
Immunoglobulin G
Transplantation
T-Lymphocytes

Keywords

  • B cell regeneration
  • Bone marrow transplantation
  • Homogeneous immunoglobulins
  • Immunodeficiency

ASJC Scopus subject areas

  • Hematology

Cite this

Homogeneous immunoglobulins following allogeneic bone marrow transplantation. / Hajdu, Melinda; Puskás, Éva; Sipos, Andrea; Barta, Anikó; Pálóczi, K.; Uher, F.

In: Acta Haematologica, Vol. 109, No. 3, 2003, p. 124-128.

Research output: Contribution to journalArticle

Hajdu, Melinda ; Puskás, Éva ; Sipos, Andrea ; Barta, Anikó ; Pálóczi, K. ; Uher, F. / Homogeneous immunoglobulins following allogeneic bone marrow transplantation. In: Acta Haematologica. 2003 ; Vol. 109, No. 3. pp. 124-128.
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