The asymmetric reduction of steroid 17- and 20-ketones with chiral hydrosilanerhodium-(+)- and (-)-diop-complex catalysts allows different stereoselectivities in the formation of 17-alchols, but not of 20-alcohols. The degree of this stereoselectivity is higher than that attained with other methods. The stereoselectivity can be explained in terms of the most preferred conformation of the α-siloxysteroid-rhodium intermediate complexes.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
- Materials Chemistry