Homogeneous and heterogeneous catalytic asymmetric reactions. II. Asymmetric hydrogenation of steroid ketones

György Göndös, Lajos Gera, M. Bartók, James C. Orr

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The asymmetric reduction of steroid 17- and 20-ketones with chiral hydrosilanerhodium-(+)- and (-)-diop-complex catalysts allows different stereoselectivities in the formation of 17-alchols, but not of 20-alcohols. The degree of this stereoselectivity is higher than that attained with other methods. The stereoselectivity can be explained in terms of the most preferred conformation of the α-siloxysteroid-rhodium intermediate complexes.

Original languageEnglish
Pages (from-to)365-375
Number of pages11
JournalJournal of Organometallic Chemistry
Volume373
Issue number3
DOIs
Publication statusPublished - Sep 19 1989

Fingerprint

Stereoselectivity
Rhodium
steroids
Hydrogenation
Ketones
rhodium
ketones
hydrogenation
alcohols
Steroids
Alcohols
catalysts
Conformations
Catalysts

ASJC Scopus subject areas

  • Biochemistry
  • Chemical Engineering (miscellaneous)
  • Inorganic Chemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Science (miscellaneous)
  • Materials Chemistry

Cite this

Homogeneous and heterogeneous catalytic asymmetric reactions. II. Asymmetric hydrogenation of steroid ketones. / Göndös, György; Gera, Lajos; Bartók, M.; Orr, James C.

In: Journal of Organometallic Chemistry, Vol. 373, No. 3, 19.09.1989, p. 365-375.

Research output: Contribution to journalArticle

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