Homogeneous and heterogeneous catalytic asymmetric reactions. II. Asymmetric hydrogenation of steroid ketones

György Göndös, Lajos Gera, Mihály Bartók, James C. Orr

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The asymmetric reduction of steroid 17- and 20-ketones with chiral hydrosilanerhodium-(+)- and (-)-diop-complex catalysts allows different stereoselectivities in the formation of 17-alchols, but not of 20-alcohols. The degree of this stereoselectivity is higher than that attained with other methods. The stereoselectivity can be explained in terms of the most preferred conformation of the α-siloxysteroid-rhodium intermediate complexes.

Original languageEnglish
Pages (from-to)365-375
Number of pages11
JournalJournal of Organometallic Chemistry
Volume373
Issue number3
DOIs
Publication statusPublished - Sep 19 1989

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Cite this