Hemoxigenáz-1 génexpresszió érett és koraszülött újszülöttekben

Translated title of the contribution: HO-1 expression in premature and mature neonates during the first week of life

Ildikó Farkas, Zoltán Maróti, M. Katona, H. Orvos, I. Németh, E. Endreffy, A. Pál, S. Túri

Research output: Contribution to journalArticle

Abstract

Newborns are exposed to mechanical and oxidative stress during labor and to relative hyperoxia thereafter during the course of adaptation to the extrauterine conditions. Part of the adaptation mechanism is the rapid degradation of fetal hemoglobin and the oxidation of its heme moiety by heme oxygenases (HOs). Heme oxygenase-1 enzyme (HO-1) is the inducible isoform, which is induced by and protective against oxidative stress. We hypothesized that HO-1 may play a role in the physiological adaptation of newborns. We therefore measured the HO-1 mRNA expression during the first week after birth in healthy mature and premature newborns. We found that HO-1 was induced until day 2 or 3 after birth, but its level had dropped below the birth HO-1 mRNA level by the end of the first week. HO-1 levels and inducibility were similar in mature newborns and premature newborns. The fact that HO-1 was inducible even in the 26. week of gestation suggests that HO-1 plays an important role in the early adaptation processes.

Original languageHungarian
Pages (from-to)251-255
Number of pages5
JournalMagyar Noorvosok Lapja
Volume67
Issue number5
Publication statusPublished - 2004

Fingerprint

Heme Oxygenase-1
Parturition
Oxidative Stress
Physiological Adaptation
Heme Oxygenase (Decyclizing)
Fetal Hemoglobin
Messenger RNA
Mechanical Stress
Hyperoxia
Heme
Protein Isoforms
Pregnancy
Enzymes

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Hemoxigenáz-1 génexpresszió érett és koraszülött újszülöttekben. / Farkas, Ildikó; Maróti, Zoltán; Katona, M.; Orvos, H.; Németh, I.; Endreffy, E.; Pál, A.; Túri, S.

In: Magyar Noorvosok Lapja, Vol. 67, No. 5, 2004, p. 251-255.

Research output: Contribution to journalArticle

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AU - Farkas, Ildikó

AU - Maróti, Zoltán

AU - Katona, M.

AU - Orvos, H.

AU - Németh, I.

AU - Endreffy, E.

AU - Pál, A.

AU - Túri, S.

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KW - Gene expression

KW - Heme oxygenase-1

KW - Neonatal adaptation

KW - Oxidative stress

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