HMG CoA Reductase Inhibitor Fluvastatin Arrests the Development of Implanted Hepatocarcinoma in Rats

György Paragh, Pal Kertai, Péter Kovacs, György Paragh, Péter Fülöp, Gabriella Foris

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35 Citations (Scopus)

Abstract

Background: Fluvastain (Flu) is widely accepted to have anticancer effect although its in vivo chemopreventive ability in cancer has not been studied. The therapeautic and chemopreventive effects of Flu were compared in vivo in the present study. Materials and Methods: Under the left renal capsule of FLFI hybrid rats 106 hepatocarcinoma cells were implanted (He/De14) on sponge disc. The differences in net weight between the left and right kidneys were determined as tumor weights. Flu was administered per os in 0.5, 2 and 20 mg/kg/day doses. Results: The 21-day pretreatment before tumor implantation with Flu had no effect on tumor development in the absence of Flu treatment after the implantation. The addition of Flu before and after tumor implantation demonstrated a more intensive anticancer effect than in the case of treatment given only after tumor implantation. Conclusion: Flu has in 0.5-20 mg/kg/day doses a therapeutic and also a preventive effect on hepatocarcinoma growth in rats depending on the type of administration.

Original languageEnglish
Pages (from-to)3949-3954
Number of pages6
JournalAnticancer research
Volume23
Issue number5 A
Publication statusPublished - Sep 1 2003

Keywords

  • Chemoprevention
  • Fluvastatin
  • Hepatocarcinoma
  • Rat
  • Tumor growth inhibition

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Paragh, G., Kertai, P., Kovacs, P., Paragh, G., Fülöp, P., & Foris, G. (2003). HMG CoA Reductase Inhibitor Fluvastatin Arrests the Development of Implanted Hepatocarcinoma in Rats. Anticancer research, 23(5 A), 3949-3954.