HLA genetic diversity in Hungarians and Hungarian Gypsies: Complementary differentiation patterns and demographic signals revealed by HLA-A, -B and -DRB1 in Central Europe

D. Inotai, A. Szilvasi, S. Benko, A. Boros-Major, Z. Illes, A. Bors, K. P. Kiss, K. Rajczy, A. Gelle-Hossó, S. Buhler, J. M. Nunes, A. Sanchez-Mazas, A. Tordai

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Systematic analyses of human leukocyte antigen (HLA) profiles in different populations may increase the efficiency of bone marrow donor selection and help reconstructing human peopling history. We typed HLA-A, -B, and -DRB1 allele groups in two bone marrow donor cohorts of 2402 Hungarians and 186 Hungarian Gypsies and compared them with several Central-European, Spanish Gypsy, and Indian populations. Our results indicate that different European Gypsy populations share a common origin but diverged genetically as a consequence of founder effect and rapid genetic drift, whereas other European populations are related genetically in relation to geography. This study also suggests that while HLA-A accurately depicts the effects of genetic drift, HLA-B, and -DRB1 conserve more signatures of ancient population relationships, as a result of balancing selection.

Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalTissue Antigens
Volume86
Issue number2
DOIs
Publication statusPublished - Aug 1 2015

Fingerprint

Roma
HLA Antigens
Demography
Genetic Drift
Population
Bone Marrow
Founder Effect
Donor Selection
Geography
History
Alleles
Tissue Donors

Keywords

  • Balancing selection
  • Bone marrow donors
  • Genetic diversity
  • Genetic drift
  • Gypsies
  • Human leukocyte antigen
  • Human leukocyte antigen evolution
  • Hungary
  • Population genetics

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Genetics

Cite this

HLA genetic diversity in Hungarians and Hungarian Gypsies : Complementary differentiation patterns and demographic signals revealed by HLA-A, -B and -DRB1 in Central Europe. / Inotai, D.; Szilvasi, A.; Benko, S.; Boros-Major, A.; Illes, Z.; Bors, A.; Kiss, K. P.; Rajczy, K.; Gelle-Hossó, A.; Buhler, S.; Nunes, J. M.; Sanchez-Mazas, A.; Tordai, A.

In: Tissue Antigens, Vol. 86, No. 2, 01.08.2015, p. 115-121.

Research output: Contribution to journalArticle

Inotai, D, Szilvasi, A, Benko, S, Boros-Major, A, Illes, Z, Bors, A, Kiss, KP, Rajczy, K, Gelle-Hossó, A, Buhler, S, Nunes, JM, Sanchez-Mazas, A & Tordai, A 2015, 'HLA genetic diversity in Hungarians and Hungarian Gypsies: Complementary differentiation patterns and demographic signals revealed by HLA-A, -B and -DRB1 in Central Europe', Tissue Antigens, vol. 86, no. 2, pp. 115-121. https://doi.org/10.1111/tan.12600
Inotai, D. ; Szilvasi, A. ; Benko, S. ; Boros-Major, A. ; Illes, Z. ; Bors, A. ; Kiss, K. P. ; Rajczy, K. ; Gelle-Hossó, A. ; Buhler, S. ; Nunes, J. M. ; Sanchez-Mazas, A. ; Tordai, A. / HLA genetic diversity in Hungarians and Hungarian Gypsies : Complementary differentiation patterns and demographic signals revealed by HLA-A, -B and -DRB1 in Central Europe. In: Tissue Antigens. 2015 ; Vol. 86, No. 2. pp. 115-121.
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