HLA-DR associations with Graves' disease in Eastern Hungary

V. Stenszky, L. Kozma, C. Balázs, N. R. Farid

Research output: Contribution to journalArticle

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Abstract

We have typed 196 patients with Graves' disease from eastern Hungary (an iodine-deficient region) for HLA-A, -B, and -C antigens and 80 of the same patients for HLA-DR antigens. Our data confirm the previously described association of HLA-B8 and DR3 with Graves' disease, particularly in patients with ophthalmopathy. We also describe several new findings: an increase in the prevalence of HLA-BW35, particularly in combination with B8, among patients with ophthalmopathy and a slight increase in the prevalence of B8, DR7 among patients with ophthalmopathy. These results support the concept that MHC-linked susceptibility to Graves' disease is dose-dependent. Our results do not confirm a report suggesting that the prevalence of HLA-DR5 is increased among patients without ophthalmopathy in iodine deficient areas: we found that the prevalence of HLA-DR5 was slightly decreased among patients with Graves' disease, with and without ophthalmopathy, in comparison with controls.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalClinical and Investigative Medicine
Volume6
Issue number3
Publication statusPublished - 1983

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Hungary
Graves Disease
HLA-DR Antigens
HLA-DR5 Antigen
Iodine
HLA-B8 Antigen
HLA-DR3 Antigen
HLA-A Antigens
HLA-B Antigens
Antigens

ASJC Scopus subject areas

  • Medicine(all)

Cite this

HLA-DR associations with Graves' disease in Eastern Hungary. / Stenszky, V.; Kozma, L.; Balázs, C.; Farid, N. R.

In: Clinical and Investigative Medicine, Vol. 6, No. 3, 1983, p. 181-184.

Research output: Contribution to journalArticle

Stenszky, V, Kozma, L, Balázs, C & Farid, NR 1983, 'HLA-DR associations with Graves' disease in Eastern Hungary', Clinical and Investigative Medicine, vol. 6, no. 3, pp. 181-184.
Stenszky, V. ; Kozma, L. ; Balázs, C. ; Farid, N. R. / HLA-DR associations with Graves' disease in Eastern Hungary. In: Clinical and Investigative Medicine. 1983 ; Vol. 6, No. 3. pp. 181-184.
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