HLA alleles and IDDM in children in Hungary: A comparison with Finland

R. Hermann, C. H. Mijovic, M. Rayner, N. Croft, M. A. Kelly, D. Jenkins, G. Soltész, A. H. Barnett

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

It has been postulated that variation in the distribution of human leukocyte antigen (HLA)-encoded susceptibility alleles for insulin-dependent diabetes mellitus (IDDM) is the genetic basis for variation in the incidence of the disease between populations. The aim of this study was to characterize HLA-encoded susceptibility to IDDM in Hungary and to identify whether HLA-DRB1/DQ-encoded susceptibility could account for the five times lower incidence of disease in Hungary compared with Finland. The haplotypes DRB1*03-DQA1*05-DQB1*02 (DRB1*03-DQ2) and DRB1*04-DQA1*0301-DQB1*0302 (DRB1*04-DQ8) were significantly associated with disease in both populations. Three genotypes incorporating either or both of these haplotypes accounted for over 70% of the diabetic population in both races. The combined background frequency and the degree of risk as measured by odds ratios of these HLA-DRB1-DQ genotypes were not significantly different in the two countries. Comparison of the DRB1*0401-DQ8 haplotype between the two races suggested a role for HLA-B alleles in susceptibility. These data indicate that the susceptibility associated with high risk DRB1-DQ genotypes alone is insufficient to account for the fivefold variation in incidence of IDDM between Hungary and Finland. Other genetic and/or environmental influences must be involved.

Original languageEnglish
Pages (from-to)391-398
Number of pages8
JournalHuman Immunology
Volume62
Issue number4
DOIs
Publication statusPublished - 2001

Fingerprint

Hungary
Finland
HLA Antigens
Type 1 Diabetes Mellitus
Alleles
Haplotypes
Genotype
Incidence
Population
Odds Ratio

Keywords

  • Finland
  • HLA alleles
  • Hungary
  • Incidence
  • Insulin-dependent diabetes mellitus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Hermann, R., Mijovic, C. H., Rayner, M., Croft, N., Kelly, M. A., Jenkins, D., ... Barnett, A. H. (2001). HLA alleles and IDDM in children in Hungary: A comparison with Finland. Human Immunology, 62(4), 391-398. https://doi.org/10.1016/S0198-8859(01)00224-5

HLA alleles and IDDM in children in Hungary : A comparison with Finland. / Hermann, R.; Mijovic, C. H.; Rayner, M.; Croft, N.; Kelly, M. A.; Jenkins, D.; Soltész, G.; Barnett, A. H.

In: Human Immunology, Vol. 62, No. 4, 2001, p. 391-398.

Research output: Contribution to journalArticle

Hermann, R, Mijovic, CH, Rayner, M, Croft, N, Kelly, MA, Jenkins, D, Soltész, G & Barnett, AH 2001, 'HLA alleles and IDDM in children in Hungary: A comparison with Finland', Human Immunology, vol. 62, no. 4, pp. 391-398. https://doi.org/10.1016/S0198-8859(01)00224-5
Hermann R, Mijovic CH, Rayner M, Croft N, Kelly MA, Jenkins D et al. HLA alleles and IDDM in children in Hungary: A comparison with Finland. Human Immunology. 2001;62(4):391-398. https://doi.org/10.1016/S0198-8859(01)00224-5
Hermann, R. ; Mijovic, C. H. ; Rayner, M. ; Croft, N. ; Kelly, M. A. ; Jenkins, D. ; Soltész, G. ; Barnett, A. H. / HLA alleles and IDDM in children in Hungary : A comparison with Finland. In: Human Immunology. 2001 ; Vol. 62, No. 4. pp. 391-398.
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