Az anaemia perniciosa terápiájának története

Translated title of the contribution: History of the therapy of pernicious anemia

Research output: Contribution to journalArticle


Increased blood cell regeneration in exsanguinated experimental animals treated either with liver or with aqueous liver extracts was reported by Whipple and by Jeney and Jobling, respectively. These findings stimulated Minot and Murphy to provide evidence for the efficacy of liver against anaemia in clinical studies. After oral administration of liver (45-50 g per day) for 45 patients with anaemia perniciosa improvement of the hematological status was demonstrated. Consequently, for proving the therapeutic value of liver therapy Whipple, Minot and Murphy received Nobel price in 1934. The isolation of the antianemic factor from the liver has been succeded in 1948 and designated as vitamin B12. At the same time Lucy Wills applied yeast for the treatment of pregnant women with anemia related to undernourisment. The conclusions of this study inspired the discovery of folate. The detailed investigation of the mode of action of vitamin B12 and folate enriched our knowledge in the area of pathophysiology and extended the clinical application of these two drugs. Orv. Hetil., 154 (44), 1754-1758.

Translated title of the contributionHistory of the therapy of pernicious anemia
Original languageHungarian
Pages (from-to)1754-1758
Number of pages5
JournalOrvosi hetilap
Issue number44
Publication statusPublished - Nov 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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