History of simple febrile seizures is associated with hippocampal abnormalities in adults

Tibor Auer, Peter Barsi, Beata Bone, Anna Angyalosi, Mihaly Aradi, Csaba Szalay, Reka A. Horvath, Norbert Kovacs, Gyula Kotek, Andras Fogarasi, Samuel Komoly, Imre Janszky, Attila Schwarcz, József Janszky

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28 Citations (Scopus)

Abstract

Background: It is unclear whether the hippocampal abnormality in temporal lobe epilepsy (TLE) is a consequence or the cause of afebrile or febrile seizures (FSs). We investigated whether hippocampal abnormalities are present in healthy adults >15 years after a simple FS. Methods: Eight healthy subjects (5 men) with a history of simple FS (FS+ group) and eight sex- and aged-matched control subjects (FS- group) were investigated by three MR methods: blinded visual inspection of the MRI pictures; automatic voxel-based volumetry; and T2 relaxation time measurements. Results: The mean total volume of the two hippocampi was 5.36 ± 1.33 cm3 in the FS+ group and 6.63 ± 1.46 cm3 in the FS- group (p = 0.069). The T2 values in the anterior part of the left hippocampus (p = 0.036) and in the middle part of the right hippocampus (p = 0.025) were elevated in the FS+ subjects. The mean volume of the right hippocampus was 3.05 ± 0.8 cm3 in the FS+ men and 4.05 ± 0.48 cm3 in the FS- men (p = 0.043). The mean total volume of the two hippocampi was 5.38 ± 1.4 cm3 in the FS+ men and 7.48 ± 1.14 cm3 in the FS- men (p = 0.043). There were three FS+ men in whom hippocampal abnormalities including hippocampal sclerosis (HS) and dysgenesis were observed on visual inspection. Conclusions: A history of simple FS in childhood can be associated with hippocampal abnormalities in adults. These abnormalities are probably more pronounced in men. Simple FS may not be as a benign event as previously thought. Our findings suggest that hippocampal abnormalities associated with FS are not necessarily epileptogenic.

Original languageEnglish
Pages (from-to)1562-1569
Number of pages8
JournalEpilepsia
Volume49
Issue number9
DOIs
Publication statusPublished - Sep 1 2008

Keywords

  • Gender differences
  • Hippocampal sclerosis
  • MRI volumetry
  • Mesial temporal lobe epilepsy
  • Simple febrile convulsions

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Auer, T., Barsi, P., Bone, B., Angyalosi, A., Aradi, M., Szalay, C., Horvath, R. A., Kovacs, N., Kotek, G., Fogarasi, A., Komoly, S., Janszky, I., Schwarcz, A., & Janszky, J. (2008). History of simple febrile seizures is associated with hippocampal abnormalities in adults. Epilepsia, 49(9), 1562-1569. https://doi.org/10.1111/j.1528-1167.2008.01679.x