Histopathology of brain metastases after radiosurgery

G. Szeifert, Douglas Kondziolka, Marc Levivier, L. Dade Lunsford

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)


Histopathological investigations revealed acute-, subacute-, and chronic-type tissue responses, accompanied by inflammatory cell reaction in radiosurgery treated cerebral metastases originating from different primary cancers. Immunohistochemistry demonstrated that the preponderance of CD68-positive macrophages and CD3-positive T lymphocytes in the inflammatory infiltration developed in better controlled metastases (> 5 months). In contrast, it was sparse or absent in poorly controlled neoplasms (<5 months) after radiosurgery. This inflammatory reaction may be stimulated by the ionizing energy, probably influenced by the general condition of the patients' immune system as well, and seems to play a role in local tumor control after focused radiation.

Original languageEnglish
Title of host publicationProgress in Neurological Surgery
Number of pages9
Publication statusPublished - 2012

Publication series

NameProgress in Neurological Surgery
ISSN (Print)00796492
ISSN (Electronic)16623924


ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Medicine(all)

Cite this

Szeifert, G., Kondziolka, D., Levivier, M., & Lunsford, L. D. (2012). Histopathology of brain metastases after radiosurgery. In Progress in Neurological Surgery (Vol. 25, pp. 30-38). (Progress in Neurological Surgery; Vol. 25). https://doi.org/10.1159/000331169