Parts of 15 corneas which were removed on the occasion of an 'a chaud' keratoplasty were examined histopathologically. It was stated that the alterations pass off in two stages. On one hand, where the corneal epithelium is totally destructed, aggregation of collagen fibers and the decrease of number of cells under the Bowman's membrane occur as an acute action of time. The quantity and regularity of glycose-aminoglycans with sulphate is declining. On the other hand, as an effect of immigrating cells, fibrinolysis is increasing. This action passes off in the neighbourhood of the cells and does not cause acute lysis of the fibers. The role of enzymes which dissolve the collagen fibers (protease, collagenase) is probably less; their action is more slow than it was suggested on the basis of animal experiments. The beneficial effect of the 'a chaud' keratoplasty may be found in the fact that the most altered upper 1/3 of the cornea will be replaced by an healthy transplantant with intact epithelium. The scar which develops in the periphery of the cornea may prevent the migration of polymorphonuclear cells from the limbus.
|Number of pages||8|
|Journal||Szemeszet Ophthalmologica Hungarica|
|Publication status||Published - Jan 1 1980|
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