Histopathological aspects and differential diagnosis of CD8 positive lymphomatoid papulosis

Márta Marschalkó, Nóra Gyöngyösi, Judit Noll, Zsuzsanna Károlyi, Norbert Wikonkál, Judit Hársing, Enikő Kuroli, Judit Csomor, A. Matolcsy, S. Kárpáti, Ágota Szepesi

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8 Citations (Scopus)

Abstract

Lymphomatoid papulosis (LyP) belongs to CD30+ lymphoproliferative disorders with indolent clinical course. Classic histological subtypes, A, B and C are characterized by the CD4+ phenotype, while CD8+ variants, most commonly classified as type D, were reported in recent years. We present 14 cases of CD8+ LyP. In all patients, self-resolving or treatment-sensitive papules were observed. Of 14 cases 7 produced results with typical microscopic features of LyP type D mimicking primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma. The infiltration pattern in 4 of 14 cases were consistent with classic LyP type B, without CD30 expression in two cases, resembling mycosis fungoides (MF). The morphology of 2 of 14 cases shared a certain consistency with classic type A and C, lacking eosinophils and neutrophils. Extensive folliculotropism characteristic to type F was observed in 1 of 14 case. Significant MUM1 and PD1 expression were detected in 2 of 14 and 3 of 14 cases, respectively. We concluded that CD8+ LyP may present with different histopathological features compared with type D, similar to CD4+ LyP variants. Differential diagnoses include CD8+ papular MF, folliculotropic MF and anaplastic large cell lymphoma in addition to primary cutaneous aggressive epidermotropic T-cell lymphoma. We emphasise that rare CD8+ LyP cases may exist with CD30-negativity.

Original languageEnglish
Pages (from-to)963-973
Number of pages11
JournalJournal of Cutaneous Pathology
Volume43
Issue number11
DOIs
Publication statusPublished - Nov 1 2016

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Keywords

  • CD30 antigen expression
  • CD8 positive cutaneous T-cell lymphoma
  • CD8 positive lymphomatoid papulosis type A,B,C,D,F
  • cutaneous CD30+ lymphoproliferative disorders
  • lymphomatoid papulosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Cite this

Marschalkó, M., Gyöngyösi, N., Noll, J., Károlyi, Z., Wikonkál, N., Hársing, J., Kuroli, E., Csomor, J., Matolcsy, A., Kárpáti, S., & Szepesi, Á. (2016). Histopathological aspects and differential diagnosis of CD8 positive lymphomatoid papulosis. Journal of Cutaneous Pathology, 43(11), 963-973. https://doi.org/10.1111/cup.12779