Histopathologic Abnormalities of the Lymphoreticular Tissues in Organic Cation Transporter 2 Deficiency: Evidence for Impaired B Cell Maturation

Katalin Komlósi, Viktória Havasi, Judit Bene, Norbert Süle, László Pajor, Raffaella Nicolai, Paola Benatti, Menotti Calvani, Béla Melegh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Immunohistology of lymphoreticular tissues of a fatal case of organic cation transporter 2 deficiency revealed inhibited proliferation with increased apoptosis in the germinal centers, resulting in "burned out" follicles. This is indicative of impaired antigen driven B cell affinity maturation. Defective humoral immune response might explain the recurrent infections in untreated organic cation transporter 2 deficiency.

Original languageEnglish
Pages (from-to)109-111.e2
JournalJournal of Pediatrics
Volume150
Issue number1
DOIs
Publication statusPublished - Jan 2007

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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