Histone Deacetylases and Autoimmunity

András Treszl, Gergó Mészáros, Gergely Toldi, B. Vásárhelyi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Adequate functionality of the immune system is required for the protection of the organism against invaders and pathogens. If immune cells react with self-epitopes, different types of autoimmune disorder may develop. An increasing amount of data supports the notion that epigenetic modifications of chromatin, particularly acetylation and deacetylation, are of central importance at different levels of prevention of autoimmunity. This review summarizes data obtained in studies of the role of histone deacetylation in the development of autoimmune disorders, and suggests the possible roles of histone deacetylase inhibitors in their treatment.

Original languageEnglish
Title of host publicationThe Epigenetics of Autoimmune Diseases
PublisherJohn Wiley and Sons
Pages385-402
Number of pages18
ISBN (Print)9780470758618
DOIs
Publication statusPublished - Apr 29 2009

Fingerprint

Acetylation
Histone Deacetylase Inhibitors
Histone Deacetylases
Immune system
Pathogens
Autoimmunity
Epigenomics
Histones
Chromatin
Epitopes
Immune System

Keywords

  • Autoimmune encephalomyelitis
  • High-mobility group box 1 (HMGB1) protein
  • Histone acetyltransferases (HATs)
  • Histone deacetylases (HDACs)
  • Non-obese diabetic (NOD) mice
  • Scleroderma, systemic autoimmune disease
  • Type 1 diabetes mellitus (T1DM)
  • Von Hippel-Lindau (VHL) ubiquitylation complex

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Treszl, A., Mészáros, G., Toldi, G., & Vásárhelyi, B. (2009). Histone Deacetylases and Autoimmunity. In The Epigenetics of Autoimmune Diseases (pp. 385-402). John Wiley and Sons. https://doi.org/10.1002/9780470743553.ch22

Histone Deacetylases and Autoimmunity. / Treszl, András; Mészáros, Gergó; Toldi, Gergely; Vásárhelyi, B.

The Epigenetics of Autoimmune Diseases. John Wiley and Sons, 2009. p. 385-402.

Research output: Chapter in Book/Report/Conference proceedingChapter

Treszl, A, Mészáros, G, Toldi, G & Vásárhelyi, B 2009, Histone Deacetylases and Autoimmunity. in The Epigenetics of Autoimmune Diseases. John Wiley and Sons, pp. 385-402. https://doi.org/10.1002/9780470743553.ch22
Treszl A, Mészáros G, Toldi G, Vásárhelyi B. Histone Deacetylases and Autoimmunity. In The Epigenetics of Autoimmune Diseases. John Wiley and Sons. 2009. p. 385-402 https://doi.org/10.1002/9780470743553.ch22
Treszl, András ; Mészáros, Gergó ; Toldi, Gergely ; Vásárhelyi, B. / Histone Deacetylases and Autoimmunity. The Epigenetics of Autoimmune Diseases. John Wiley and Sons, 2009. pp. 385-402
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