Histological studies of bovine herpesvirus type 4 infection in non-ruminant species

L. Egyed, J. P. Kluge, A. Bartha

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The pathology of bovine herpesvirus type 4 (BHV-4) infection was studied in cats, rabbits and guinea pigs. Twenty kittens, twenty-two rabbits and ten guinea pigs, some treated with glucocorticoid were inoculated with a BHV-4 strain of feline origin, via various routes of inoculation (conjunctival, intranasal, peritoneal). Clinical signs were recorded. After euthanizing at different post inoculation days macro- and microscopic changes were observed by necropsy and in hematoxylin-eosin stained histological sections. The presence of the virus in organs was detected by immunohistochemistry and a nested PCR assay. Inclusion bodies and monoclonal antibody-stained cells were found in the conjunctiva, trachea, lungs, spleen and lymph nodes. Most of the lesions were localized to the respiratory and the immune system. The macro- and microscopic lesions and clinical signs were more severe in kittens and guinea pigs. The histological data indicated that cats, especially kittens, were susceptible for BHV-4 and the infection was not confined to the urinary bladder.

Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalVeterinary Microbiology
Volume57
Issue number2-3
DOIs
Publication statusPublished - Sep 1997

Fingerprint

Bovine Herpesvirus 4
Bovine herpesvirus 4
Herpesviridae Infections
kittens
guinea pigs
Guinea Pigs
cats
lesions (animal)
Cats
rabbits
infection
Rabbits
conjunctiva
trachea (vertebrates)
Conjunctiva
Inclusion Bodies
Felidae
inclusion bodies
Hematoxylin
Eosine Yellowish-(YS)

Keywords

  • Bovine herpesvirus type 4
  • Experimental infection
  • Histology
  • Non-ruminant species
  • PCR

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Microbiology
  • veterinary(all)

Cite this

Histological studies of bovine herpesvirus type 4 infection in non-ruminant species. / Egyed, L.; Kluge, J. P.; Bartha, A.

In: Veterinary Microbiology, Vol. 57, No. 2-3, 09.1997, p. 283-289.

Research output: Contribution to journalArticle

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