Histological lesions in vascular tissues of bovine herpes virus type 4-infected rabbits

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The gamma-herpes virus bovine herpes virus type 4 (BoHV-4) is distributed worldwide in cattle populations with unknown pathogenicity. Bovine endothelial cells were recently shown to be susceptible to BoHV-4 infection in vitro and this virus accelerated the cholesterol-induced atherosclerotic process in rabbits. In this study, the in vivo effect of BoHV-4 on cardiovascular tissue was investigated by intravenous infection of rabbits fed a cholesterol free diet. Inflammatory lesions of vascular tissue in aortic and valvular endothelial cells, and smooth muscle cells were detected by H&E staining, PCR, IF, EM immunohistochemistry, while virus isolation was used to detect virus particles. Acute and chronic vasculitis, signs of chronic endocarditis, with mononuclear cell accumulation and a fresh thrombus was found. Herpes viruses have already been thought to initiate cardio-vascular disorders, now this paper shows that a bovine gamma-herpes virus could also be a causative agent of vascular lesions in mammals fed a normal diet. BoHV-4-infection of rabbits could serve as a useful animal model for research into virus-induced human cardio-vascular diseases.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalVeterinary Microbiology
Volume91
Issue number1
DOIs
Publication statusPublished - Jan 2 2003

Fingerprint

vascular tissues
lesions (animal)
Blood Vessels
rabbits
Rabbits
Viruses
viruses
cattle
Virus Diseases
Endothelial Cells
Cholesterol
cardiovascular diseases
endothelial cells
Diet
cholesterol
infection
Vasculitis
Endocarditis
endocarditis
vasculitis

Keywords

  • Bovine herpesvirus type 4
  • Cardio-vascular system
  • Histology
  • Rabbit

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Microbiology
  • veterinary(all)

Cite this

Histological lesions in vascular tissues of bovine herpes virus type 4-infected rabbits. / Egyed, L.; Baska, F.

In: Veterinary Microbiology, Vol. 91, No. 1, 02.01.2003, p. 1-10.

Research output: Contribution to journalArticle

@article{7cd7ba2296ff475389326a57453139e7,
title = "Histological lesions in vascular tissues of bovine herpes virus type 4-infected rabbits",
abstract = "The gamma-herpes virus bovine herpes virus type 4 (BoHV-4) is distributed worldwide in cattle populations with unknown pathogenicity. Bovine endothelial cells were recently shown to be susceptible to BoHV-4 infection in vitro and this virus accelerated the cholesterol-induced atherosclerotic process in rabbits. In this study, the in vivo effect of BoHV-4 on cardiovascular tissue was investigated by intravenous infection of rabbits fed a cholesterol free diet. Inflammatory lesions of vascular tissue in aortic and valvular endothelial cells, and smooth muscle cells were detected by H&E staining, PCR, IF, EM immunohistochemistry, while virus isolation was used to detect virus particles. Acute and chronic vasculitis, signs of chronic endocarditis, with mononuclear cell accumulation and a fresh thrombus was found. Herpes viruses have already been thought to initiate cardio-vascular disorders, now this paper shows that a bovine gamma-herpes virus could also be a causative agent of vascular lesions in mammals fed a normal diet. BoHV-4-infection of rabbits could serve as a useful animal model for research into virus-induced human cardio-vascular diseases.",
keywords = "Bovine herpesvirus type 4, Cardio-vascular system, Histology, Rabbit",
author = "L. Egyed and F. Baska",
year = "2003",
month = "1",
day = "2",
doi = "10.1016/S0378-1135(02)00261-4",
language = "English",
volume = "91",
pages = "1--10",
journal = "Veterinary Microbiology",
issn = "0378-1135",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Histological lesions in vascular tissues of bovine herpes virus type 4-infected rabbits

AU - Egyed, L.

AU - Baska, F.

PY - 2003/1/2

Y1 - 2003/1/2

N2 - The gamma-herpes virus bovine herpes virus type 4 (BoHV-4) is distributed worldwide in cattle populations with unknown pathogenicity. Bovine endothelial cells were recently shown to be susceptible to BoHV-4 infection in vitro and this virus accelerated the cholesterol-induced atherosclerotic process in rabbits. In this study, the in vivo effect of BoHV-4 on cardiovascular tissue was investigated by intravenous infection of rabbits fed a cholesterol free diet. Inflammatory lesions of vascular tissue in aortic and valvular endothelial cells, and smooth muscle cells were detected by H&E staining, PCR, IF, EM immunohistochemistry, while virus isolation was used to detect virus particles. Acute and chronic vasculitis, signs of chronic endocarditis, with mononuclear cell accumulation and a fresh thrombus was found. Herpes viruses have already been thought to initiate cardio-vascular disorders, now this paper shows that a bovine gamma-herpes virus could also be a causative agent of vascular lesions in mammals fed a normal diet. BoHV-4-infection of rabbits could serve as a useful animal model for research into virus-induced human cardio-vascular diseases.

AB - The gamma-herpes virus bovine herpes virus type 4 (BoHV-4) is distributed worldwide in cattle populations with unknown pathogenicity. Bovine endothelial cells were recently shown to be susceptible to BoHV-4 infection in vitro and this virus accelerated the cholesterol-induced atherosclerotic process in rabbits. In this study, the in vivo effect of BoHV-4 on cardiovascular tissue was investigated by intravenous infection of rabbits fed a cholesterol free diet. Inflammatory lesions of vascular tissue in aortic and valvular endothelial cells, and smooth muscle cells were detected by H&E staining, PCR, IF, EM immunohistochemistry, while virus isolation was used to detect virus particles. Acute and chronic vasculitis, signs of chronic endocarditis, with mononuclear cell accumulation and a fresh thrombus was found. Herpes viruses have already been thought to initiate cardio-vascular disorders, now this paper shows that a bovine gamma-herpes virus could also be a causative agent of vascular lesions in mammals fed a normal diet. BoHV-4-infection of rabbits could serve as a useful animal model for research into virus-induced human cardio-vascular diseases.

KW - Bovine herpesvirus type 4

KW - Cardio-vascular system

KW - Histology

KW - Rabbit

UR - http://www.scopus.com/inward/record.url?scp=0037413294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037413294&partnerID=8YFLogxK

U2 - 10.1016/S0378-1135(02)00261-4

DO - 10.1016/S0378-1135(02)00261-4

M3 - Article

C2 - 12441227

AN - SCOPUS:0037413294

VL - 91

SP - 1

EP - 10

JO - Veterinary Microbiology

JF - Veterinary Microbiology

SN - 0378-1135

IS - 1

ER -