Histological evaluation of chemotherapeutically induced tumour regression

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Examinations were performed on 30 patients with biopsy-confirmed differentiated epithelial cancer of the oral cavity in clinical stage T2-3N0-2M0. The aim of the present study was to perform a histological evaluation of the effect of preoperative intra-arterial treatment on surgically removed tumours. The tumour regression (R) was evaluated quantitatively on a scale ranging between 1 and 4. The evaluation yielded a value of R1 in 8/30 cases (residual tumour was not found histologically). A tumour of microscopic size (R2) was found in 5/30 cases, partial regression (R3) was established in 12/30 cases, and a slight response (R4) in 5/30 patients. The tumour regression was evaluated qualitatively on the basis of three arbitrarily chosen parameters. Examinations were made of the morphological picture of the residual cancer, the inflammatory reaction of the stroma (S) and the demarcation tendency of the tumour (D) and the sum of these values (A). The qualitative evaluation of the residual tumour can yield a point score in the range A3-9. The higher this point score, the poorer is the response of the tumour in question. Tumours with a score of A3-5 proved to have a very favourable prognosis, in contrast to those with a score of A8-9. For the borderline scores of A6-7 the subsequent fate of the patient was decided by the extent of the original tumour and by the occurrence or not of metastases. It is noteworthy that, with a comparatively small number of patients, a significant correlation was demonstrated between the survival and the total qualitative point count (A), the S value and the D value.

Original languageEnglish
Pages (from-to)313-319
Number of pages7
JournalRegional Cancer Treatment
Issue number5-6
Publication statusPublished - Dec 1 1992

ASJC Scopus subject areas

  • Oncology
  • Pharmacology

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