Histological and thermodynamical features of cathepsin B-positive tumors of non-small cell lung cancer obtained by syntactic structure analysis

Jan Dirk Baumhäkel, Klaus Kayser, E. Kálmán, Janko Kos, Tamara Lah, Eberhard Spiess, Werner Ebert, Walter Fiehn, Bernd Werle

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cellular orders in normal tissue and in tumors can be described on the basis of physical terms. Assuming that the peptidase cathepsin B is involved as an essential factor in tumor progression we analyzed the corresponding distribution pattern and determined the entropy of this cell fraction in tumors by syntactic structure analysis using nearest neighbor relationships. Of the 120 surveyed sections from primary lung tumors 62 (51.7%) were identified with cathepsin B expressing cells. Cathepsin B-positive tumor cells have significantly shorter mean cell-cell distances (p

Original languageEnglish
Pages (from-to)59-70
Number of pages12
JournalElectronic Journal of Pathology and Histology
Volume7
Issue number1
Publication statusPublished - 2001

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Cathepsin B
Non-Small Cell Lung Carcinoma
tripeptide aminopeptidase
Neoplasms
Entropy
Lung

Keywords

  • Cathepsin B
  • Entropy
  • Non-small cell lung cancer
  • Syntactic structure analysis
  • Thermodynamic features

ASJC Scopus subject areas

  • Anatomy
  • Histology

Cite this

Histological and thermodynamical features of cathepsin B-positive tumors of non-small cell lung cancer obtained by syntactic structure analysis. / Baumhäkel, Jan Dirk; Kayser, Klaus; Kálmán, E.; Kos, Janko; Lah, Tamara; Spiess, Eberhard; Ebert, Werner; Fiehn, Walter; Werle, Bernd.

In: Electronic Journal of Pathology and Histology, Vol. 7, No. 1, 2001, p. 59-70.

Research output: Contribution to journalArticle

Baumhäkel, Jan Dirk ; Kayser, Klaus ; Kálmán, E. ; Kos, Janko ; Lah, Tamara ; Spiess, Eberhard ; Ebert, Werner ; Fiehn, Walter ; Werle, Bernd. / Histological and thermodynamical features of cathepsin B-positive tumors of non-small cell lung cancer obtained by syntactic structure analysis. In: Electronic Journal of Pathology and Histology. 2001 ; Vol. 7, No. 1. pp. 59-70.
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AU - Kálmán, E.

AU - Kos, Janko

AU - Lah, Tamara

AU - Spiess, Eberhard

AU - Ebert, Werner

AU - Fiehn, Walter

AU - Werle, Bernd

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