Zur Histochemie der limbischen Hemmung - Zytochemische und autoradiographische Untersuchungen über die Lokalisation der Enzyme des Gamma-amino-Buttersäure- Stoffwechsels im Hippocampus der Ratte

Translated title of the contribution: Histochemistry of the limbic inhibition

B. Csillik, A. M. Gerebtzoff, J. Kiss, E. Knyihár-Csillik

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

GABA-metabolism in the rat hippocampal formation has been studied by means of classical chromogenic histochemistry (localisation of the GABA-transaminase→succinic semialdehyde dehydrogenase system) and by means of light- and electron microscopic autoradiographic localization of the enzyme-inhibitor 14C-thiosemicarbazide. Both the histochemical and the autoradiographic approaches proved a gliocellular localization of GABA metabolism, concentrated at glio-neuronal interfaces. Contradictory data of relevant biochemical literature can readily be explained on the basis of these results, offering new perspectives for neurophysiological interpretation and pharmacotherapeutical treatment of behavioral limbic disorders.

Original languageGerman
Pages (from-to)38-54
Number of pages17
JournalHistochemie
Volume28
Issue number1
DOIs
Publication statusPublished - Mar 1971

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Enzyme inhibition
Metabolism
gamma-Aminobutyric Acid
metabolism
Chromogenics
enzyme inhibitors
Rats
dehydrogenases
Enzymes
Enzyme Inhibitors
rats
Electrons
Hippocampus
Oxidoreductases
disorders
Light
electrons

ASJC Scopus subject areas

  • Instrumentation
  • Cell Biology
  • Medicine(all)

Cite this

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abstract = "GABA-metabolism in the rat hippocampal formation has been studied by means of classical chromogenic histochemistry (localisation of the GABA-transaminase→succinic semialdehyde dehydrogenase system) and by means of light- and electron microscopic autoradiographic localization of the enzyme-inhibitor 14C-thiosemicarbazide. Both the histochemical and the autoradiographic approaches proved a gliocellular localization of GABA metabolism, concentrated at glio-neuronal interfaces. Contradictory data of relevant biochemical literature can readily be explained on the basis of these results, offering new perspectives for neurophysiological interpretation and pharmacotherapeutical treatment of behavioral limbic disorders.",
author = "B. Csillik and Gerebtzoff, {A. M.} and J. Kiss and E. Knyih{\'a}r-Csillik",
year = "1971",
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AU - Gerebtzoff, A. M.

AU - Kiss, J.

AU - Knyihár-Csillik, E.

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