Histochemical tumor markers for evaluation of hormone dependence in breast cancer.

P. J. Klein, M. Vierbuchen, K. D. Schulz, G. Farrar, J. Fischer, G. Uhlenbruck, R. Fischer

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Abstract

Lectin from the peanut (peanut agglutinin = PNA) possesses a high affinity for D-galactosyl-(1-3)-N-acetyl-D-galactosamine, used for histochemical investigations on formalin-fixed tissue sections of normal mammary gland as well as of benign and malignant breast diseases. Thereby, a lectin-binding pattern was found that partly exhibited secretory malfunction. Additional studies with a labeled antibody directed against a milk fat globule membrane glycoprotein, which was isolated by PNA affinity chromatography from human milk, confirmed the PNA receptor as a marker of a milk protein in breast carcinomas. The most important clinicopathological finding, however, was that in accordance with the secretory activity about 77% of PNA-positive tumors responded to endocrine treatment, whereas PNA-negative mammary carcinomas usually failed to show any response to hormonal therapy. These results also correlated with the hormone receptor content of tumor tissue.

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalCancer Detection and Prevention
Volume6
Issue number1-2
Publication statusPublished - Jan 1 1983

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Klein, P. J., Vierbuchen, M., Schulz, K. D., Farrar, G., Fischer, J., Uhlenbruck, G., & Fischer, R. (1983). Histochemical tumor markers for evaluation of hormone dependence in breast cancer. Cancer Detection and Prevention, 6(1-2), 199-206.