Histochemical tumor markers for evaluation of hormone dependence in breast cancer.

P. J. Klein, M. Vierbuchen, K. D. Schulz, G. Farrar, J. Fischer, G. Uhlenbruck, R. Fischer

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Lectin from the peanut (peanut agglutinin = PNA) possesses a high affinity for D-galactosyl-(1-3)-N-acetyl-D-galactosamine, used for histochemical investigations on formalin-fixed tissue sections of normal mammary gland as well as of benign and malignant breast diseases. Thereby, a lectin-binding pattern was found that partly exhibited secretory malfunction. Additional studies with a labeled antibody directed against a milk fat globule membrane glycoprotein, which was isolated by PNA affinity chromatography from human milk, confirmed the PNA receptor as a marker of a milk protein in breast carcinomas. The most important clinicopathological finding, however, was that in accordance with the secretory activity about 77% of PNA-positive tumors responded to endocrine treatment, whereas PNA-negative mammary carcinomas usually failed to show any response to hormonal therapy. These results also correlated with the hormone receptor content of tumor tissue.

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalCancer Detection and Prevention
Volume6
Issue number1-2
Publication statusPublished - 1983

Fingerprint

Peanut Agglutinin
Tumor Biomarkers
Hormones
Breast Neoplasms
Acetylgalactosamine
Breast Diseases
Milk Proteins
Membrane Glycoproteins
Human Milk
Human Mammary Glands
Affinity Chromatography
Lectins
Formaldehyde
Neoplasms
Antibodies
Therapeutics
milk fat globule

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Klein, P. J., Vierbuchen, M., Schulz, K. D., Farrar, G., Fischer, J., Uhlenbruck, G., & Fischer, R. (1983). Histochemical tumor markers for evaluation of hormone dependence in breast cancer. Cancer Detection and Prevention, 6(1-2), 199-206.

Histochemical tumor markers for evaluation of hormone dependence in breast cancer. / Klein, P. J.; Vierbuchen, M.; Schulz, K. D.; Farrar, G.; Fischer, J.; Uhlenbruck, G.; Fischer, R.

In: Cancer Detection and Prevention, Vol. 6, No. 1-2, 1983, p. 199-206.

Research output: Contribution to journalArticle

Klein, PJ, Vierbuchen, M, Schulz, KD, Farrar, G, Fischer, J, Uhlenbruck, G & Fischer, R 1983, 'Histochemical tumor markers for evaluation of hormone dependence in breast cancer.', Cancer Detection and Prevention, vol. 6, no. 1-2, pp. 199-206.
Klein PJ, Vierbuchen M, Schulz KD, Farrar G, Fischer J, Uhlenbruck G et al. Histochemical tumor markers for evaluation of hormone dependence in breast cancer. Cancer Detection and Prevention. 1983;6(1-2):199-206.
Klein, P. J. ; Vierbuchen, M. ; Schulz, K. D. ; Farrar, G. ; Fischer, J. ; Uhlenbruck, G. ; Fischer, R. / Histochemical tumor markers for evaluation of hormone dependence in breast cancer. In: Cancer Detection and Prevention. 1983 ; Vol. 6, No. 1-2. pp. 199-206.
@article{5627d3c622aa4bce869e9b10d4dbabd2,
title = "Histochemical tumor markers for evaluation of hormone dependence in breast cancer.",
abstract = "Lectin from the peanut (peanut agglutinin = PNA) possesses a high affinity for D-galactosyl-(1-3)-N-acetyl-D-galactosamine, used for histochemical investigations on formalin-fixed tissue sections of normal mammary gland as well as of benign and malignant breast diseases. Thereby, a lectin-binding pattern was found that partly exhibited secretory malfunction. Additional studies with a labeled antibody directed against a milk fat globule membrane glycoprotein, which was isolated by PNA affinity chromatography from human milk, confirmed the PNA receptor as a marker of a milk protein in breast carcinomas. The most important clinicopathological finding, however, was that in accordance with the secretory activity about 77{\%} of PNA-positive tumors responded to endocrine treatment, whereas PNA-negative mammary carcinomas usually failed to show any response to hormonal therapy. These results also correlated with the hormone receptor content of tumor tissue.",
author = "Klein, {P. J.} and M. Vierbuchen and Schulz, {K. D.} and G. Farrar and J. Fischer and G. Uhlenbruck and R. Fischer",
year = "1983",
language = "English",
volume = "6",
pages = "199--206",
journal = "Cancer Epidemiology",
issn = "1877-7821",
publisher = "Elsevier BV",
number = "1-2",

}

TY - JOUR

T1 - Histochemical tumor markers for evaluation of hormone dependence in breast cancer.

AU - Klein, P. J.

AU - Vierbuchen, M.

AU - Schulz, K. D.

AU - Farrar, G.

AU - Fischer, J.

AU - Uhlenbruck, G.

AU - Fischer, R.

PY - 1983

Y1 - 1983

N2 - Lectin from the peanut (peanut agglutinin = PNA) possesses a high affinity for D-galactosyl-(1-3)-N-acetyl-D-galactosamine, used for histochemical investigations on formalin-fixed tissue sections of normal mammary gland as well as of benign and malignant breast diseases. Thereby, a lectin-binding pattern was found that partly exhibited secretory malfunction. Additional studies with a labeled antibody directed against a milk fat globule membrane glycoprotein, which was isolated by PNA affinity chromatography from human milk, confirmed the PNA receptor as a marker of a milk protein in breast carcinomas. The most important clinicopathological finding, however, was that in accordance with the secretory activity about 77% of PNA-positive tumors responded to endocrine treatment, whereas PNA-negative mammary carcinomas usually failed to show any response to hormonal therapy. These results also correlated with the hormone receptor content of tumor tissue.

AB - Lectin from the peanut (peanut agglutinin = PNA) possesses a high affinity for D-galactosyl-(1-3)-N-acetyl-D-galactosamine, used for histochemical investigations on formalin-fixed tissue sections of normal mammary gland as well as of benign and malignant breast diseases. Thereby, a lectin-binding pattern was found that partly exhibited secretory malfunction. Additional studies with a labeled antibody directed against a milk fat globule membrane glycoprotein, which was isolated by PNA affinity chromatography from human milk, confirmed the PNA receptor as a marker of a milk protein in breast carcinomas. The most important clinicopathological finding, however, was that in accordance with the secretory activity about 77% of PNA-positive tumors responded to endocrine treatment, whereas PNA-negative mammary carcinomas usually failed to show any response to hormonal therapy. These results also correlated with the hormone receptor content of tumor tissue.

UR - http://www.scopus.com/inward/record.url?scp=0020698460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020698460&partnerID=8YFLogxK

M3 - Article

C2 - 6192918

AN - SCOPUS:0020698460

VL - 6

SP - 199

EP - 206

JO - Cancer Epidemiology

JF - Cancer Epidemiology

SN - 1877-7821

IS - 1-2

ER -