Histochemical and ultrastructural study of renal cortical necrosis in rats treated with oestrone + vasopressin, and its prevention with a vasopressin antagonist

J. Kocsis, G. Karacsony, S. Karcsu, F. László

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Abstract

Renal cortical necrosis was induced by the administration of vasopressin to oestrogen-pretreated rats. Histochemical (succinic dehydrogenase, trichrome, perjod acid Schiff) and electronmicroscopic methods were applied to examine how the vasopressin antagonist d(CH2)5 Tyr(Met)AVP influences the development of this renal cortical necrosis. The experiments revealed that vasopressin did not induce hypoxia or necrosis in the renal tubules if the antagonist was administered simultaneously, even after oestrogen pretreatment. The conclusion is drawn that this pressor antagonist may be of value for the prevention of renal cortical necrosis in rats or in human beings.

Original languageEnglish
Pages (from-to)35-43
Number of pages9
JournalBritish Journal of Experimental Pathology
Volume68
Issue number1
Publication statusPublished - 1987

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Kidney Cortex Necrosis
Estrone
Vasopressins
Estrogens
Succinate Dehydrogenase
Acids
Antidiuretic Hormone Receptor Antagonists

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

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abstract = "Renal cortical necrosis was induced by the administration of vasopressin to oestrogen-pretreated rats. Histochemical (succinic dehydrogenase, trichrome, perjod acid Schiff) and electronmicroscopic methods were applied to examine how the vasopressin antagonist d(CH2)5 Tyr(Met)AVP influences the development of this renal cortical necrosis. The experiments revealed that vasopressin did not induce hypoxia or necrosis in the renal tubules if the antagonist was administered simultaneously, even after oestrogen pretreatment. The conclusion is drawn that this pressor antagonist may be of value for the prevention of renal cortical necrosis in rats or in human beings.",
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AU - Karacsony, G.

AU - Karcsu, S.

AU - László, F.

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Y1 - 1987

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