Ultrastructural and histochemical changes of skeletal muscle were studied in 3 fatal cases of gas gangrene. There was complete lack of the phosphorylase, succinate dehydrogenase and adenosine triphosphatase activities in the affected muscles of all the patients. In unaffected muscles these enzymes showed weaker activities than normal. The lactate dehydrogenase activity, especially the heart type isozyme (LDH 1 or H4) proved less sensitive to the effect of clostridial toxin. A general increase in the acid phosphatase activity was found both in affected and in unaffected muscles. On electron microscopic examination damage to sarcolemmal membrane and disintegration of myofilaments was seen. The mitochondria were swollen and their cristae distorted and fragmented.
|Number of pages||6|
|Journal||Folia Histochemica et Cytochemica|
|Publication status||Published - Dec 1 1975|
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