Histochemical and electron microscopical studies of skeletal muscle affected by gas gangrene

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Ultrastructural and histochemical changes of skeletal muscle were studied in 3 fatal cases of gas gangrene. There was complete lack of the phosphorylase, succinate dehydrogenase and adenosine triphosphatase activities in the affected muscles of all the patients. In unaffected muscles these enzymes showed weaker activities than normal. The lactate dehydrogenase activity, especially the heart type isozyme (LDH 1 or H4) proved less sensitive to the effect of clostridial toxin. A general increase in the acid phosphatase activity was found both in affected and in unaffected muscles. On electron microscopic examination damage to sarcolemmal membrane and disintegration of myofilaments was seen. The mitochondria were swollen and their cristae distorted and fragmented.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalFolia Histochemica et Cytochemica
Issue number3-4
Publication statusPublished - Dec 1 1975


ASJC Scopus subject areas

  • Medicine(all)

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