Histochemical and atomic absorption demonstration of trace metal mobilization in the central nervous system and liver of the rat

A. Ferke, M. Kozma, K. Bánsághy, P. Kása

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Abstract

Histochemical and atomic absorption spectrophotometric analysis of trace metal mobilization caused by the action of ethanol in the central nervous system (CNS) and liver of the rat is described. Histochemically it has been shown that in all neurons examined (motoneurons, pyramidal and Purkinje cells) the trace metals (mainly Zn2+ and Cu2+) are mobilized. Most of the stained materials disappear from the perikaryon of the Purkinje cells, while in both the motoneurons and the pyramidal cells the trace metals are displaced from the perikaryon into the axon and axon hillock. At the same time, some of the glia cells display a high metal content. Quantitative determination of the Zn2+ and Cu2+ by means of atomic absorption spectrophotometry reveals that after 2 hours ethanol treatment both the Zn2+ and the Cu2+ levels are decreased in the archicerebellar cortex, while after 4 hours the Zn2+ levels are increased in the cerebrum and the spinal cord. The present observations on the histochemical localization and the contents of zinc and copper in different parts of the CNS and liver reveal the important role of the effect of ethanol on the trace metal mobilization.

Original languageEnglish
Pages (from-to)295-303
Number of pages9
JournalHistochemistry
Volume59
Issue number4
DOIs
Publication statusPublished - Dec 1979

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Central Nervous System
Metals
Liver
Ethanol
Pyramidal Cells
Purkinje Cells
Motor Neurons
Atomic Spectrophotometry
Cerebrum
Neuroglia
Axons
Zinc
Copper
Spinal Cord
Neurons

ASJC Scopus subject areas

  • Anatomy

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Histochemical and atomic absorption demonstration of trace metal mobilization in the central nervous system and liver of the rat. / Ferke, A.; Kozma, M.; Bánsághy, K.; Kása, P.

In: Histochemistry, Vol. 59, No. 4, 12.1979, p. 295-303.

Research output: Contribution to journalArticle

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