Histamine-stimulated prostaglandin synthesis in rat brain microvessels

E. Dux, F. Joó, A. Gecse, Zs Mezei, L. Dux, J. Hideg, G. Telegdy

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The histamine-sensitivity of prostacyclin and prostaglandin synthesis was investigated in isolated brain microvessels prepared from normal and hypoxic exercised rats. 10-4M histamine stimulated the in vitro synthesis of all components of arachidonate cascade. The chronic hypoxic exercise also resulted in an enhanced production of each fraction. Hypoxia and histamine showed an additive effect in the synthesis of PGE2 only. The possible molecular mechanism induced by hypoxia and histamine is discussed.

Original languageEnglish
Pages (from-to)146-148
Number of pages3
JournalAgents and Actions
Volume12
Issue number1-2
DOIs
Publication statusPublished - Apr 1982

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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