Histamine Regulates Placental Cytokine Expression - In vivo Study on HDC Knockout Mice

E. Pap, A. Falus, D. Mihályi, H. Borck, F. Diel, É Pállinger

Research output: Contribution to journalArticle

6 Citations (Scopus)


Successful pregnancy is closely related to polarization toward a Th2 type immune response. As histamine is known to initiate Th2 dominance during inflammatory processes we raised the question whether histamine has any effect on the actual tuning of proper cytokine balance for the proceeding of the gestation. Histamine has multiple functions in the process of pregnancy, different studies have shown the direct and/or indirect presence of histamine action in the placenta as well. As HDC is the unique histamine producing enzyme in eukaryotes, we used HDC (so endogenous histamine)-deficient knockout mice as reliable model for studying histamine-related processes in vivo. We examined the placental histamine content and the expression of histamine receptors and Th1/Th2/Th3 type cytokines in the placenta. We showed for the first time the influence of histamine on the orchestrated regulation of placental cytokine expression. In the absence of local histamine the cytokine balance is shifted toward Th1 types at the maternal-placental interface, threatening pregnancy. We also measured splenic lymphocyte subpopulation ratios in pregnant and non-pregnant mice and found that in pregnancy they are independent of the presence of histamine.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
Issue number2-3
Publication statusPublished - Feb 1 2007


  • Histamine
  • Histamine receptors
  • Lymphocyte subsets
  • Placental cytokine expression

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Histamine Regulates Placental Cytokine Expression - In vivo Study on HDC Knockout Mice'. Together they form a unique fingerprint.

  • Cite this