Histamine potentiates human platelet aggregation induced by platelet-activating factor

S. Sipka, M. Koltai, P. Braquet, G. Szegedi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Using human platelet-rich plasma (PRP) we found that histamine concentration-dependently potentiated platelet aggregation induced by platelet-activating factor (PAF). When added separately, neither histamine nor chloropyramine, a competitive antagonist of H1 receptors, influenced platelet aggregation, however BN 52021, a specific PAF receptor antagonist, concentration-dependently inhibited the response. Chloropyramine reduced the potentiating effect of histamine on PAF-induced platelet aggregation, and when it was coadministered with BN 52021, inducing 63% inhibition of PAF-induced aggregation, the histamine-potentiated PAF response was completely abolished. This observation draws attention to the importance of cooperation between histamine and PAF in mediation of platelet aggregation in human PRP, and points to the powerful antiaggregatory effect of BN 52021 combined with an antagonist of H1 receptors.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalInternational Archives of Allergy and Immunology
Volume97
Issue number1
Publication statusPublished - 1992

Fingerprint

ginkgolide B
Platelet Activating Factor
Platelet Aggregation
Histamine
Histamine H1 Receptors
Platelet-Rich Plasma

Keywords

  • BN 52021
  • chloropyramine
  • histamine
  • platelet aggregation
  • platelet-activating factor
  • platelet-rich plasma, human

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Histamine potentiates human platelet aggregation induced by platelet-activating factor. / Sipka, S.; Koltai, M.; Braquet, P.; Szegedi, G.

In: International Archives of Allergy and Immunology, Vol. 97, No. 1, 1992, p. 89-92.

Research output: Contribution to journalArticle

@article{3de89435e29249bc844d8d876b804501,
title = "Histamine potentiates human platelet aggregation induced by platelet-activating factor",
abstract = "Using human platelet-rich plasma (PRP) we found that histamine concentration-dependently potentiated platelet aggregation induced by platelet-activating factor (PAF). When added separately, neither histamine nor chloropyramine, a competitive antagonist of H1 receptors, influenced platelet aggregation, however BN 52021, a specific PAF receptor antagonist, concentration-dependently inhibited the response. Chloropyramine reduced the potentiating effect of histamine on PAF-induced platelet aggregation, and when it was coadministered with BN 52021, inducing 63{\%} inhibition of PAF-induced aggregation, the histamine-potentiated PAF response was completely abolished. This observation draws attention to the importance of cooperation between histamine and PAF in mediation of platelet aggregation in human PRP, and points to the powerful antiaggregatory effect of BN 52021 combined with an antagonist of H1 receptors.",
keywords = "BN 52021, chloropyramine, histamine, platelet aggregation, platelet-activating factor, platelet-rich plasma, human",
author = "S. Sipka and M. Koltai and P. Braquet and G. Szegedi",
year = "1992",
language = "English",
volume = "97",
pages = "89--92",
journal = "International Archives of Allergy and Immunology",
issn = "1018-2438",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Histamine potentiates human platelet aggregation induced by platelet-activating factor

AU - Sipka, S.

AU - Koltai, M.

AU - Braquet, P.

AU - Szegedi, G.

PY - 1992

Y1 - 1992

N2 - Using human platelet-rich plasma (PRP) we found that histamine concentration-dependently potentiated platelet aggregation induced by platelet-activating factor (PAF). When added separately, neither histamine nor chloropyramine, a competitive antagonist of H1 receptors, influenced platelet aggregation, however BN 52021, a specific PAF receptor antagonist, concentration-dependently inhibited the response. Chloropyramine reduced the potentiating effect of histamine on PAF-induced platelet aggregation, and when it was coadministered with BN 52021, inducing 63% inhibition of PAF-induced aggregation, the histamine-potentiated PAF response was completely abolished. This observation draws attention to the importance of cooperation between histamine and PAF in mediation of platelet aggregation in human PRP, and points to the powerful antiaggregatory effect of BN 52021 combined with an antagonist of H1 receptors.

AB - Using human platelet-rich plasma (PRP) we found that histamine concentration-dependently potentiated platelet aggregation induced by platelet-activating factor (PAF). When added separately, neither histamine nor chloropyramine, a competitive antagonist of H1 receptors, influenced platelet aggregation, however BN 52021, a specific PAF receptor antagonist, concentration-dependently inhibited the response. Chloropyramine reduced the potentiating effect of histamine on PAF-induced platelet aggregation, and when it was coadministered with BN 52021, inducing 63% inhibition of PAF-induced aggregation, the histamine-potentiated PAF response was completely abolished. This observation draws attention to the importance of cooperation between histamine and PAF in mediation of platelet aggregation in human PRP, and points to the powerful antiaggregatory effect of BN 52021 combined with an antagonist of H1 receptors.

KW - BN 52021

KW - chloropyramine

KW - histamine

KW - platelet aggregation

KW - platelet-activating factor

KW - platelet-rich plasma, human

UR - http://www.scopus.com/inward/record.url?scp=0026560158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026560158&partnerID=8YFLogxK

M3 - Article

C2 - 1582704

AN - SCOPUS:0026560158

VL - 97

SP - 89

EP - 92

JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

SN - 1018-2438

IS - 1

ER -