Histamine influences the expression of the interleukin-6 receptor on human lymphoid, monocytoid and hepatoma cell lines

K. Merétey, A. Falus, T. Taga, T. Kishimoto

Research output: Contribution to journalArticle

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Abstract

Based on our earlier data on the enhancing effect of histamine on the action of interleukin-6 (IL-6), we have studied the molecular mechanisms of these interactions. The effect of histamine was investigated on the binding of125I-IL-6 by B lymphoma cell line CESS, monocytoid cell line U937 and hepatoma cell line HepG2. Histamine increases the IL-6 binding by CESS cells and inhibits that by U937 and HepG2 cells. Using H1 receptor (cetirizin and loderix) and H2 receptor (cimetidine and ranitidine) specific antagonists, an H1-dependent stimulation of IL-6 binding by CESS cells was found. In contrast, down-regulation of IL-6 binding by histamine was clearly mediated through H2 receptors. On U937 cells, using a monoclonal antibody reacting with the 80 kd chain of the human IL-6 receptor, an H2-receptor mediated inhibition of IL-6 receptor expression was found by FACS analysis.

Original languageEnglish
Pages (from-to)189-191
Number of pages3
JournalAgents and Actions
Volume33
Issue number1-2
DOIs
Publication statusPublished - May 1991

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Interleukin-6 Receptors
Histamine
Hepatocellular Carcinoma
Interleukin-6
U937 Cells
Histamine H2 Receptors
Cells
Cell Line
Histamine H1 Receptors
Ranitidine
Cimetidine
Hep G2 Cells
Lymphoma
Down-Regulation
Monoclonal Antibodies

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Cite this

Histamine influences the expression of the interleukin-6 receptor on human lymphoid, monocytoid and hepatoma cell lines. / Merétey, K.; Falus, A.; Taga, T.; Kishimoto, T.

In: Agents and Actions, Vol. 33, No. 1-2, 05.1991, p. 189-191.

Research output: Contribution to journalArticle

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