Histamine H2-receptors participate in the formation of brain edema induced by kainic acid in rat thalamus

L. Sztriha, Ferenc Joó, Péter Szerdahelyi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

At 4 h after the intraperitoneal administration of kainic acid in a dose of 12 mg/kg, Evans blue extravasation was observed preferentially in the thalamus, accompanied by increases in the water and sodium contents and by a decrease in the potassium content. Subcutaneous pretreatment with a histamine H2-receptor blocking agent, ranitidine, in a dose of 5 mg/kg given 2 h before and at the time of kainic acid injection, partially decreased the edema formation in the thalamus. It is assumed that repetitive discharges evoked by the kainic acid result in the thalamus in an excessive release of histamine from internal (mast cell and neuronal) sources and that this leads to the activation of H2-receptor-coupled adenylate cyclase in the brain microvessels and to the induction of brain edema.

Original languageEnglish
Pages (from-to)334-338
Number of pages5
JournalNeuroscience Letters
Volume75
Issue number3
DOIs
Publication statusPublished - Apr 10 1987

Fingerprint

Histamine H2 Receptors
Kainic Acid
Brain Edema
Thalamus
Evans Blue
Ranitidine
Histamine Release
Microvessels
Adenylyl Cyclases
Mast Cells
Edema
Potassium
Sodium
Injections
Water
Brain

Keywords

  • Brain edema
  • Histamine receptor
  • Kainic acid
  • Ranitidine
  • Rat
  • Seizure

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Histamine H2-receptors participate in the formation of brain edema induced by kainic acid in rat thalamus. / Sztriha, L.; Joó, Ferenc; Szerdahelyi, Péter.

In: Neuroscience Letters, Vol. 75, No. 3, 10.04.1987, p. 334-338.

Research output: Contribution to journalArticle

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