Histamine H1 and H2 receptors but not H4 receptors are upregulated during bone marrow regeneration

Zsuzsanna Horváth, E. Pállinger, Gyozo Horváth, Ivett Jelinek, A. Falus, E. Búzás

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The role of histamine receptors in radiation-induced bone marrow (BM) regeneration was investigated with aspects of functional genomics. H1R and H2R mRNA expression increased during regeneration in both histidine decarboxylase knockout (HDC-/-) and wild type (HDC+/+) mice, though to a lesser extent in HDC-/- mice. H4R mRNA expression was downregulated in both groups. Mainly CD34+ cells were responsible for the elevation of intracellular histamine and HDC content in HDC+/+ BM cell populations. The differential changes in the expression of its receptors, and also its elevated levels in hematopoietic progenitors support the regulatory role of histamine in BM regeneration, that could be further explored by future gene expression studies.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalCellular Immunology
Volume244
Issue number2
DOIs
Publication statusPublished - Dec 2006

Fingerprint

Histidine Decarboxylase
Histamine H1 Receptors
Histamine H2 Receptors
Bone Regeneration
Histamine
Bone Marrow
Histamine Receptors
Messenger RNA
Genomics
Knockout Mice
Bone Marrow Cells
Regeneration
Down-Regulation
Radiation
Gene Expression
Population

Keywords

  • Bone marrow
  • Gene expression
  • H1R
  • H2R
  • H4R
  • HDC
  • Histamine receptor
  • Regeneration

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Histamine H1 and H2 receptors but not H4 receptors are upregulated during bone marrow regeneration. / Horváth, Zsuzsanna; Pállinger, E.; Horváth, Gyozo; Jelinek, Ivett; Falus, A.; Búzás, E.

In: Cellular Immunology, Vol. 244, No. 2, 12.2006, p. 110-115.

Research output: Contribution to journalArticle

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