Histamine Genomics and Metabolomics

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Histamine, one of the most abundantly studied general mediators, is a 112 Da biogenic amine generated by histidine decarboxylase (HDC) from L-histidine. Histamine binds to at least four different G-protein-associated plasma membrane receptors (H1-H4) with dissimilar tissue expression patterns and various biological functions. It plays an important role in the regulation of immune and inflammatory processes and, based on recent studies, is involved in malignant and normal cell proliferation. Both synthetizing and degradating enzymes, as well as histamine receptors, reveal significant, functionally relevant genetic polymorphism. The phenotype of the gene-targeted HDC-'knock-out' mice suggests that histamine, part of metabolome, is a major player in the regulation of mammalian physiology and pathophysiology.

Original languageEnglish
Title of host publicationImmunogenomics and Human Disease
PublisherJohn Wiley & Sons, Ltd
Pages371-394
Number of pages24
ISBN (Print)9780470015308
DOIs
Publication statusPublished - May 16 2006

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Keywords

  • Androgen-binding protein (ABP)
  • Biosynthesis
  • Biotransformation
  • Gram-positive bacteria
  • Ovariectomy-induced osteoporosis
  • Ring tautomerism
  • Side-chain conformation
  • Signal-transduction machinery
  • Trans-splicing mechanism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Falus, A., Hegyesi, H., Darvas, S., Pos, Z., & Igaz, P. (2006). Histamine Genomics and Metabolomics. In Immunogenomics and Human Disease (pp. 371-394). John Wiley & Sons, Ltd. https://doi.org/10.1002/0470034092.ch16