Histamine elevates the expression of Ets-1, a protooncogen in human melanoma cell lines through H2 receptor

H. Hegyesi, Barnabás Horváth, E. Pállinger, Z. Pós, Viktor Molnár, A. Falus

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Histamine is known to act, at least in part, as a growth factor for several cell types, and as production of this biogen amine has been found to accelerate the rate of tissue proliferation in wound repair, embryogenesis and malignant growth. Abundant experimental and clinical data suggest that histamine augments in vivo tumour cell proliferation via histamine H2 receptors (H2R). Here, we report that exogenously added histamine stimulates Ets-1 (v-ets erythroblastosis virus E26 oncogene homolog 1) synthesis in human melanoma cells. Involvement of histamine receptors in the histamine induced ets-1 expression has been also studied. Our data show that these newly recognized actions of histamine are mediated by the H2R. Modification of local protooncogen Ets-1 level is likely being involved in the regulation of melanoma growth.

Original languageEnglish
Pages (from-to)2475-2479
Number of pages5
JournalFEBS Letters
Volume579
Issue number11
DOIs
Publication statusPublished - Apr 25 2005

Fingerprint

Histamine H2 Receptors
Histamine
Melanoma
Cells
Cell Line
Histamine Receptors
Growth
Oncogenes
Embryonic Development
Amines
Cell proliferation
Intercellular Signaling Peptides and Proteins
Viruses
Cell Proliferation
Tumors
Repair
Tissue
Wounds and Injuries
Neoplasms

Keywords

  • Ets-1
  • Histamine receptor
  • Human melanoma
  • Protooncogen

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Histamine elevates the expression of Ets-1, a protooncogen in human melanoma cell lines through H2 receptor. / Hegyesi, H.; Horváth, Barnabás; Pállinger, E.; Pós, Z.; Molnár, Viktor; Falus, A.

In: FEBS Letters, Vol. 579, No. 11, 25.04.2005, p. 2475-2479.

Research output: Contribution to journalArticle

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