Hippocampal mobility-related theta activity is not diminished by vigabatrin, a GABAmimetic antiepileptic drug, in normal rats

A. Ylinen, E. Koivisto, A. Valjakka, J. Sirviö, T. Freund, P. Riekkinen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Lesions causing loss of hippocampal theta activity have been shown to result in spatial memory deficits in rats. On the other hand, hippocampal theta activity is thought to be associated only with motor activity, and its role in learning/memory is not clear. Vigabatrin, an inhibitor of GABA-transaminase, causes elevation of brain GABA levels. Previously, we have found that subchronic administration of vigabatrin did not impair spatial learning/memory in a water maze task. This experiment was carried out to further examine the hippocampal effects of vigabatrin by studying whether vigabatrin at antiepileptic doses affects mobility-related hippocampal EEG. Administration of vigabatrin (100 mg/kg or 500 mg/kg, IP) to nonepileptic rats caused no significant changes in mobility-related rhythmic theta activity, and the relative spectral power of theta frequency had a slight increasing tendency. These results suggest that the vigabatrin-induced enhanced GABAergic inhibition does not disturb normal mobility-related hippocampal theta activity.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalBrain Research Bulletin
Volume28
Issue number1
DOIs
Publication statusPublished - 1992

Fingerprint

Vigabatrin
Anticonvulsants
4-Aminobutyrate Transaminase
Memory Disorders
gamma-Aminobutyric Acid
Electroencephalography
Motor Activity
Learning
Water
Brain

Keywords

  • GABAmimetic
  • Hippocampus
  • Theta rhythm
  • Vigabatrin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hippocampal mobility-related theta activity is not diminished by vigabatrin, a GABAmimetic antiepileptic drug, in normal rats. / Ylinen, A.; Koivisto, E.; Valjakka, A.; Sirviö, J.; Freund, T.; Riekkinen, P.

In: Brain Research Bulletin, Vol. 28, No. 1, 1992, p. 145-147.

Research output: Contribution to journalArticle

Ylinen, A. ; Koivisto, E. ; Valjakka, A. ; Sirviö, J. ; Freund, T. ; Riekkinen, P. / Hippocampal mobility-related theta activity is not diminished by vigabatrin, a GABAmimetic antiepileptic drug, in normal rats. In: Brain Research Bulletin. 1992 ; Vol. 28, No. 1. pp. 145-147.
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