Hippocampal kindling-induced after-discharge and behavioural depression: immediate and long-term attenuation by opiate antagonists

Georgia A. Cottrell, Csaba Nyakas, Béla Bohus

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Abstract

Hippocampal kindling results in tonic-clonic convulsions followed by a pronounced period of behavioural depression. The effect of the opiate antagonists, naltrexone and naloxone, on the duration of the after-discharge and behavioural depression was investigated. Naltrexone, injected s.c. 60 min before, significantly reduced the behavioural depression at doses as low as 0.06 mg/kg, but had no effect on the after-discharge even at higher doses. One day later, the behavioural depression was still reduced in some animals and the after-discharge was significantly decreased following the higher doses (0.24-0.48 mg/kg). Naloxone, injected s.c., 10 min before, significantly reduced the behavioural depression at a dose as low as 0.002 mg/kg and also reduced the duration of the after-discharge at some doses. Naloxone did not exert any significant effects 24 h later. Naltrexone, injected i.c. 60 min before kindling in a dose of 1 μg, significantly attenuated the behavioural depression and had no effect on the after-discharge. The behavioural depression was still attenuated 24 and 48 h later. The involvement of μ-receptor-related endogenous opioid mechanisms in postictal brain processes is suggested. The long-term effects might be related to receptor 'activation' during the immediate period due to an interaction between the antagonist and the kindling experience.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalEuropean Journal of Pharmacology
Volume150
Issue number1-2
DOIs
Publication statusPublished - May 20 1988

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Keywords

  • (Behavioural depression, After-discharge)
  • Hippocampal kindling
  • Naloxone
  • Naltrexone

ASJC Scopus subject areas

  • Pharmacology

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