Hippocampal kindling: corticosterone modulation of induced seizures

G. A. Cottrell, C. Nyakas, E. R. De Kloet, B. Bohus

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The effect of adrenalectomy (ADX) and corticosterone replacement was studied on seizures induced by hippocampal kindling. A complex series of changes occurred in after-discharge (AD) and behavioural depression (BD) during the immediate hours after ADX, culminating at day 1 in markedly decreased AD and BD, which returned to normal over the next several days. These changes were normalized after replacement of the ADX group with low doses of corticosterone. It is concluded that the expression and maintenance of hippocampal kindled seizures is under short-term control of corticosterone.

Original languageEnglish
Pages (from-to)377-381
Number of pages5
JournalBrain Research
Volume309
Issue number2
DOIs
Publication statusPublished - Sep 10 1984

Fingerprint

Corticosterone
Seizures
Adrenalectomy
Maintenance

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Hippocampal kindling : corticosterone modulation of induced seizures. / Cottrell, G. A.; Nyakas, C.; De Kloet, E. R.; Bohus, B.

In: Brain Research, Vol. 309, No. 2, 10.09.1984, p. 377-381.

Research output: Contribution to journalArticle

Cottrell, G. A. ; Nyakas, C. ; De Kloet, E. R. ; Bohus, B. / Hippocampal kindling : corticosterone modulation of induced seizures. In: Brain Research. 1984 ; Vol. 309, No. 2. pp. 377-381.
@article{d954db9ef560412fa1d94558397c4f00,
title = "Hippocampal kindling: corticosterone modulation of induced seizures",
abstract = "The effect of adrenalectomy (ADX) and corticosterone replacement was studied on seizures induced by hippocampal kindling. A complex series of changes occurred in after-discharge (AD) and behavioural depression (BD) during the immediate hours after ADX, culminating at day 1 in markedly decreased AD and BD, which returned to normal over the next several days. These changes were normalized after replacement of the ADX group with low doses of corticosterone. It is concluded that the expression and maintenance of hippocampal kindled seizures is under short-term control of corticosterone.",
author = "Cottrell, {G. A.} and C. Nyakas and {De Kloet}, {E. R.} and B. Bohus",
year = "1984",
month = "9",
day = "10",
doi = "10.1016/0006-8993(84)90608-5",
language = "English",
volume = "309",
pages = "377--381",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Hippocampal kindling

T2 - corticosterone modulation of induced seizures

AU - Cottrell, G. A.

AU - Nyakas, C.

AU - De Kloet, E. R.

AU - Bohus, B.

PY - 1984/9/10

Y1 - 1984/9/10

N2 - The effect of adrenalectomy (ADX) and corticosterone replacement was studied on seizures induced by hippocampal kindling. A complex series of changes occurred in after-discharge (AD) and behavioural depression (BD) during the immediate hours after ADX, culminating at day 1 in markedly decreased AD and BD, which returned to normal over the next several days. These changes were normalized after replacement of the ADX group with low doses of corticosterone. It is concluded that the expression and maintenance of hippocampal kindled seizures is under short-term control of corticosterone.

AB - The effect of adrenalectomy (ADX) and corticosterone replacement was studied on seizures induced by hippocampal kindling. A complex series of changes occurred in after-discharge (AD) and behavioural depression (BD) during the immediate hours after ADX, culminating at day 1 in markedly decreased AD and BD, which returned to normal over the next several days. These changes were normalized after replacement of the ADX group with low doses of corticosterone. It is concluded that the expression and maintenance of hippocampal kindled seizures is under short-term control of corticosterone.

UR - http://www.scopus.com/inward/record.url?scp=0021261154&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021261154&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(84)90608-5

DO - 10.1016/0006-8993(84)90608-5

M3 - Article

C2 - 6541077

AN - SCOPUS:0021261154

VL - 309

SP - 377

EP - 381

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -