Highly selective deuteration of pharmaceutically relevant nitrogen-containing heterocycles: A flow chemistry approach

Sándor B. Ötvös, István M. Mándity, Ferenc Fülöp

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A simple and efficient flow-based technique is reported for the catalytic deuteration of several model nitrogen-containing heterocyclic compounds which are important building blocks of pharmacologically active materials. A continuous flow reactor was used in combination with on-demand pressure-controlled electrolytic D 2 production. The D 2 source was D 2O, the consumption of which was very low. The experimental set-up allows the fine-tuning of pressure, temperature, and flow rate so as to determine the optimal conditions for the deuteration reactions. The described procedure lacks most of the drawbacks of the conventional batch deuteration techniques, and additionally is highly selective and reproducible.

Original languageEnglish
Pages (from-to)605-611
Number of pages7
JournalMolecular Diversity
Volume15
Issue number3
DOIs
Publication statusPublished - Aug 1 2011

Keywords

  • Deuteration
  • Flow chemistry
  • Heterogeneous catalysis
  • Nitrogen-containing heterocycles
  • Reduction

ASJC Scopus subject areas

  • Catalysis
  • Information Systems
  • Molecular Biology
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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