Highly efficient encapsulation of curcumin into and pH-controlled drug release from poly(ε-caprolactone) nanoparticles stabilized with a novel amphiphilic hyperbranched polyglycerol

N. Zs. Nagy, Z. Varga, J. Mihály, Gy Kasza, B. Iván, Kiss

Research output: Contribution to journalArticle

Abstract

The hardly water-soluble curcumin with low bioavailability was successfully encapsulated into biodegradable polymeric particles by nanoprecipitation. By using the more hydrophobic poly(ε-caprolactone) (PCL) instead of poly(lactic-co-glycolic acid) 50:50 (PLGA) significantly increased drug load was achieved. The stronger interaction between curcumin and PCL than PLGA was supported by Fourier-transform infrared spectroscopy (FTIR) measurements. As efficient colloid stabilizer, a novel amphiphilic polymer, hyperbranched polyglycerol with one long alkyl chain (C18-HbPG) was used which has better membrane affinity than the widely used Pluronics, and it enables further functionalization of the drug carrier as well. A Box-Behnken experimental design was applied to prepare and optimize the properties of curcumin loaded PCL nanoparticles (NPs) varying the initial drug load, composition of the organic phase and volume ratio of aqueous and organic phases. The volume of the organic phase was found to be the most relevant parameter for encapsulation, and it can be used to control the size and drug content of the NPs. The curcumin load of 10 w/w% of the NPs with diameter below 120 nm was observed in the optimal system. Cumulative controlled release of curcumin with strong pH-dependence into simulated gastric fluids with up to ~80% is found after 8–12 hours.

Original languageEnglish
Pages (from-to)90-101
Number of pages12
JournalExpress Polymer Letters
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2020

Fingerprint

Dendrimers
Polycaprolactone
biochemistry
Biochemistry
Biodegradable polymers
Drug Carriers
Curcumin
dendrimers
Polymethyl Methacrylate
Sols
Encapsulation
Nanostructured materials
Fourier transform infrared spectroscopy
drugs
Nanoparticles
nanoparticles
Pharmaceutical Preparations
Optimal systems
Colloids
bioavailability

Keywords

  • Curcumin
  • Drug carrier
  • Hyperbranched polyglycerol
  • Nanomaterials
  • Polycaprolactone

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cite this

Highly efficient encapsulation of curcumin into and pH-controlled drug release from poly(ε-caprolactone) nanoparticles stabilized with a novel amphiphilic hyperbranched polyglycerol. / Zs. Nagy, N.; Varga, Z.; Mihály, J.; Kasza, Gy; Iván, B.; Kiss.

In: Express Polymer Letters, Vol. 14, No. 1, 01.2020, p. 90-101.

Research output: Contribution to journalArticle

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