Higher serum eosinophil cationic protein levels in children with cow's milk allergy

Edit Hidvégi, Endre Cserháti, Erzsébet Kereki, A. Arató

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: In the pathogenesis of cow's milk allergy, abnormal immunologically mediated reactions play a basic role. Eosinophil activation also participates in the development of several allergies. The purpose of this study was to characterize the degree of this activation by measuring the serum level of eosinophil cationic protein (sECP) and establishing whether it is a useful parameter in monitoring oral cow's milk allergy. Methods: The sECP level of 35 patients with previously confirmed cow's milk allergy (mean age, 16 months) was evaluated using a fluoroimmunoassay before the cow's milk rechallenge test and ar 2 hours and 24 hours after cow's milk challenge. Results: Of the 35 children with previously confirmed cow's milk allergy, 10 had positive clinical reactions after the milk rechallenge test, whereas 25 children had no reaction. The median sECP level of all the patients before the challenge test was significantly higher (12.4 μg/L) than that of the control group (4.3 μg/L) (P <0.05). Two hours after the challenge, the median sECP of all patients (9.4 μg/L) was lower than the starting values. The median sECP levels were higher in children with positive challenge test results at all time points. However, this difference was not statistically significant. Conclusions: The normalization of sECP level may indicate the cessation of the cow's milk allergy. Therefore, the measurement of sECP may be helpful in determining the optimal time in which to repeat the challenge test, when the result will more likely be negative. The significant decrease of the sECP level 2 hours after the beginning of milk challenge test may be explained by the fact that this protein is excreted into the intestinal lumen.

Original languageEnglish
Pages (from-to)475-479
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume32
Issue number4
DOIs
Publication statusPublished - 2001

Fingerprint

milk allergy
Milk Hypersensitivity
Eosinophil Cationic Protein
eosinophils
milk
milk analysis
Milk
proteins
Fluoroimmunoassay
testing
Eosinophils
hypersensitivity
Hypersensitivity
mouth
pathogenesis
Control Groups

Keywords

  • Allergy
  • Child
  • Cow's milk
  • Eosinophil cationic protein

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Higher serum eosinophil cationic protein levels in children with cow's milk allergy. / Hidvégi, Edit; Cserháti, Endre; Kereki, Erzsébet; Arató, A.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 32, No. 4, 2001, p. 475-479.

Research output: Contribution to journalArticle

Hidvégi, Edit ; Cserháti, Endre ; Kereki, Erzsébet ; Arató, A. / Higher serum eosinophil cationic protein levels in children with cow's milk allergy. In: Journal of Pediatric Gastroenterology and Nutrition. 2001 ; Vol. 32, No. 4. pp. 475-479.
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AB - Background: In the pathogenesis of cow's milk allergy, abnormal immunologically mediated reactions play a basic role. Eosinophil activation also participates in the development of several allergies. The purpose of this study was to characterize the degree of this activation by measuring the serum level of eosinophil cationic protein (sECP) and establishing whether it is a useful parameter in monitoring oral cow's milk allergy. Methods: The sECP level of 35 patients with previously confirmed cow's milk allergy (mean age, 16 months) was evaluated using a fluoroimmunoassay before the cow's milk rechallenge test and ar 2 hours and 24 hours after cow's milk challenge. Results: Of the 35 children with previously confirmed cow's milk allergy, 10 had positive clinical reactions after the milk rechallenge test, whereas 25 children had no reaction. The median sECP level of all the patients before the challenge test was significantly higher (12.4 μg/L) than that of the control group (4.3 μg/L) (P <0.05). Two hours after the challenge, the median sECP of all patients (9.4 μg/L) was lower than the starting values. The median sECP levels were higher in children with positive challenge test results at all time points. However, this difference was not statistically significant. Conclusions: The normalization of sECP level may indicate the cessation of the cow's milk allergy. Therefore, the measurement of sECP may be helpful in determining the optimal time in which to repeat the challenge test, when the result will more likely be negative. The significant decrease of the sECP level 2 hours after the beginning of milk challenge test may be explained by the fact that this protein is excreted into the intestinal lumen.

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