High-yielding synthesis of 3-alkoxycarbonyl- and 3-carboxamido-3-tropene derivatives in homogeneous carbonylation reactions of 3-iodo-2-tropene

László Horváth, Zoltán Berente, László Kollár

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

3-Iodo-2-tropene, synthesized from the corresponding ketone (tropinone) via its hydrazone, was carbonylated in palladium-catalyzed alkoxy- and aminocarbonylation reactions. The new synthetic approach provided the corresponding 3-carboxylic acid derivatives of pharmacological importance in chemospecific reactions and isolated in up to 87 % yields.

Original languageEnglish
Pages (from-to)124-127
Number of pages4
JournalLetters in Organic Chemistry
Volume2
Issue number2
DOIs
Publication statusPublished - Mar 1 2005

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Keywords

  • Alkoxycarbonylation
  • Arninocarbonylation
  • Homogeneous catalysis
  • Palladium
  • Tropane-skeleton

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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