High-resolution melting curve analysis to establish CYP2C19*2 single nucleotide polymorphism: Comparison with hydrolysis SNP analysis

Manna Temesvári, József Paulik, László Kóbori, Katalin Monostory

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Clinically significant consequences of CYP2C19 polymorphism in drug metabolism require reliable genotyping methods for assaying large numbers of blood samples. Hydrolysis single nucleotide polymorphism analysis and high-resolution melting curve (HRM) analysis successfully genotyped the 114 liver donors for CYP2C19*2. However, the HRM analysis was found to be more efficient, rapid, user- and cost-friendly method.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalMolecular and Cellular Probes
Volume25
Issue number2-3
DOIs
Publication statusPublished - Apr 1 2011

    Fingerprint

Keywords

  • CYP2C19*2
  • High-resolution melting curve analysis
  • Hydrolysis SNP analysis
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this