Clinically significant consequences of CYP2C19 polymorphism in drug metabolism require reliable genotyping methods for assaying large numbers of blood samples. Hydrolysis single nucleotide polymorphism analysis and high-resolution melting curve (HRM) analysis successfully genotyped the 114 liver donors for CYP2C19*2. However, the HRM analysis was found to be more efficient, rapid, user- and cost-friendly method.
- High-resolution melting curve analysis
- Hydrolysis SNP analysis
- Single nucleotide polymorphism
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology