High rate of early restenosis after carotid eversion endarterectomy in homozygous carriers of the normal mannose-binding lectin genotype

Szabolcs Rugonfalvi-Kiss, Edit Dósa, Hans O. Madsen, V. Endrész, Z. Prohászka, Judit Laki, I. Karádi, E. Gönczöl, L. Selmeci, László Romics, G. Füst, L. Entz, Peter Garred

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Background and Purpose - Mannose-binding lectin (MBL) is thought to influence the pathophysiology of cardiovascular disease by decreasing the risk of advanced atherosclerosis and by contributing to enhanced ischemia reperfusion injury. Thus, we investigated the role of MBL in restenosis after eversion endarterectomy in patients with severe carotid atherosclerosis. Methods - In a prospective study, 123 patients who underwent carotid endarterectomy were followed-up by carotid duplex scan (CDS) sonography for 14 months. In a retrospective study, we examined 17 patients and 29 patients, respectively, who had or had not at least 50% restenosis 29 months after carotid eversion endarterectomy. MBL genotypes were analyzed by a polymerase chain reaction-based method, and MBL serum concentrations were measured. Results - In the prospective study in the patients homozygous for the normal MBL genotype, CDS values were significantly higher after 14 months of follow-up compared with the values measured 6 weeks after surgery (P

Original languageEnglish
Pages (from-to)944-948
Number of pages5
JournalStroke
Volume36
Issue number5
DOIs
Publication statusPublished - May 2005

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Mannose-Binding Lectin
Carotid Endarterectomy
Genotype
Prospective Studies
Endarterectomy
Carotid Artery Diseases
Reperfusion Injury
Ultrasonography
Atherosclerosis
Cardiovascular Diseases
Retrospective Studies
Polymerase Chain Reaction
Serum

Keywords

  • Atherosclerosis
  • Cardiovascular disease
  • Carotid endarterectomy
  • Carotid stenosis
  • Complement
  • Genetics
  • Ischemia
  • Mannose-binding lectin
  • MBL2
  • Reperfusion injury

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

High rate of early restenosis after carotid eversion endarterectomy in homozygous carriers of the normal mannose-binding lectin genotype. / Rugonfalvi-Kiss, Szabolcs; Dósa, Edit; Madsen, Hans O.; Endrész, V.; Prohászka, Z.; Laki, Judit; Karádi, I.; Gönczöl, E.; Selmeci, L.; Romics, László; Füst, G.; Entz, L.; Garred, Peter.

In: Stroke, Vol. 36, No. 5, 05.2005, p. 944-948.

Research output: Contribution to journalArticle

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AU - Rugonfalvi-Kiss, Szabolcs

AU - Dósa, Edit

AU - Madsen, Hans O.

AU - Endrész, V.

AU - Prohászka, Z.

AU - Laki, Judit

AU - Karádi, I.

AU - Gönczöl, E.

AU - Selmeci, L.

AU - Romics, László

AU - Füst, G.

AU - Entz, L.

AU - Garred, Peter

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