High pressure–low flow remodeling of the rat saphenous vein wall

Judit R. Hetthéssy, Anna Mária Tőkés, Sándor Kérész, Petra Balla, Gabriella Dörnyei, Emil Monos, György L. Nádasy

Research output: Contribution to journalArticle

5 Citations (Scopus)


Objective: To better understand factors that may play a role in the development of varicosities. Methods: We induced combined flow-pressure disturbance in the saphenous system of the rat by performing chronic partial clipping of the main branch. Biomechanical and quantitative histological testing was undertaken. Results: A rich microvenous network developed. Bloodflow decreased to 0.65 ± 0.18 µl/s (control side, 3.5 ± 1.4 µl/s) and pressure elevated to 6.8 ± 0.7 mmHg (control side, 2.3 ± 0.2 mmHg, p < 0.05). Involution of the wall and lumen was observed (16.5%, 28.7% and 35.5% reduction in outer diameter, wall thickness and wall mass respectively, p < 0.05). Elevated macrophage (CD68) and cell division (Ki67) activity was observed. Elastic tissue and smooth muscle actin became less concentrated in the inner medial layers. Conclusions: Low-flow induced morphological shrinking of the lumen in veins may override pressure-induced morphological distension. Loosening of the force-bearing elements during flow-induced wall remodeling may be an important pathological component in varicosity.

Original languageEnglish
Pages (from-to)128-137
Number of pages10
Issue number2
Publication statusPublished - Mar 1 2018


  • Saphenous vein
  • microcirculatory changes
  • varicose veins
  • venous disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'High pressure–low flow remodeling of the rat saphenous vein wall'. Together they form a unique fingerprint.

  • Cite this