High pressure–low flow remodeling of the rat saphenous vein wall

Judit R. Hetthéssy, A. Tőkés, Sándor Kérész, Petra Balla, Gabriella Dörnyei, E. Monos, G. Nádasy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To better understand factors that may play a role in the development of varicosities. Methods: We induced combined flow-pressure disturbance in the saphenous system of the rat by performing chronic partial clipping of the main branch. Biomechanical and quantitative histological testing was undertaken. Results: A rich microvenous network developed. Bloodflow decreased to 0.65 ± 0.18 µl/s (control side, 3.5 ± 1.4 µl/s) and pressure elevated to 6.8 ± 0.7 mmHg (control side, 2.3 ± 0.2 mmHg, p < 0.05). Involution of the wall and lumen was observed (16.5%, 28.7% and 35.5% reduction in outer diameter, wall thickness and wall mass respectively, p < 0.05). Elevated macrophage (CD68) and cell division (Ki67) activity was observed. Elastic tissue and smooth muscle actin became less concentrated in the inner medial layers. Conclusions: Low-flow induced morphological shrinking of the lumen in veins may override pressure-induced morphological distension. Loosening of the force-bearing elements during flow-induced wall remodeling may be an important pathological component in varicosity.

Original languageEnglish
Pages (from-to)128-137
Number of pages10
JournalPhlebology
Volume33
Issue number2
DOIs
Publication statusPublished - Mar 1 2018

Fingerprint

Saphenous Vein
Pressure
Elastic Tissue
Cell Division
Smooth Muscle
Actins
Veins
Macrophages

Keywords

  • microcirculatory changes
  • Saphenous vein
  • varicose veins
  • venous disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

High pressure–low flow remodeling of the rat saphenous vein wall. / Hetthéssy, Judit R.; Tőkés, A.; Kérész, Sándor; Balla, Petra; Dörnyei, Gabriella; Monos, E.; Nádasy, G.

In: Phlebology, Vol. 33, No. 2, 01.03.2018, p. 128-137.

Research output: Contribution to journalArticle

Hetthéssy, Judit R. ; Tőkés, A. ; Kérész, Sándor ; Balla, Petra ; Dörnyei, Gabriella ; Monos, E. ; Nádasy, G. / High pressure–low flow remodeling of the rat saphenous vein wall. In: Phlebology. 2018 ; Vol. 33, No. 2. pp. 128-137.
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